15O-H2O PET/CT as a tool for the quantitative assessement of early post-radiotherapy changes of heart perfusion in breast carcinoma patients.

CONCLUSION: 15O-H2O PET/CT is safe and effective for the early detection and quantitative analysis of subclinical post-radiotherapy changes in heart perfusion in breast cancer patients. The LV segments supplied by the LAD are the main site of MBF changes. A minimum radiation dose deposited in the LAD may be a predictor of radiation-induced heart toxicity. Advances in knowledge: This is the first time that 15O-H2O PET/CT has been used to assess MBF after radiotherapy and the first granular description of the distribution of blood flow changes after breast cancer radiotherapy. PMID: 29470136 [PubMed - as supplied by publisher]
Source: The British Journal of Radiology - Category: Radiology Authors: Tags: Br J Radiol Source Type: research