The evolutionary impact of Intragenic FliA Promoters in Proteobacteria

This article is protected by copyright. All rights reserved. Recent findings have identified thousands of bacterial promoters in unexpected locations, such as inside genes. Here, we investigate the functions of intragenic promoters for the flagellar sigma factor FliA. Our data suggest that most of these promoters are not functional, but that one intragenic FliA promoter is broadly conserved, and constrains evolution of the overlapping protein‐coding gene. Our data suggest that intragenic regulatory sequences significantly impact bacterial genome evolution.
Source: Molecular Microbiology - Category: Microbiology Authors: Tags: Research Article Source Type: research