Combined thorax-abdomen extraction in a Maastricht type III donor.

[Combined thorax-abdomen extraction in a Maastricht type III donor]. An Sist Sanit Navar. 2018 Feb 21;0(0):62266 Authors: Barber Ansón M, García Herrera AN, Roldán Ramírez J, Loinaz Bordonabe M, Agudo Pascual O, Osés Munarriz I Abstract Donation after circulatory death (Maastricht type III donation) or controlled cardiac death refers to the retrieval of organs for transplantation purposes following death confirmed using circulatory criteria after the withdrawal of life support. The persistent shortfall in organ availability has prompted the development of donation programs following circulatory death for lung transplantation. The combined thorax-abdomen extraction in these cases is carried out in only twelve centres in Spain, while the combined use of abdominal normothermic regional perfusion (NRP) is even more exceptional. The first case of pulmonary and abdominal extraction in a Maastricht type III donor in Navarre with this type of preservation techniques is a milestone and the success achieved shows that it is a feasible and safe procedure. PMID: 29465089 [PubMed - as supplied by publisher]
Source: Anales del Sistema Sanitario de Navarra - Category: General Medicine Authors: Tags: An Sist Sanit Navar Source Type: research

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Publication date: Available online 20 August 2018Source: Indian Heart JournalAuthor(s): Shayan Marsia, Ariba Khan, Maryam Khan, Saba Ahmed, Javeria Hayat, Abdul Mannan Khan Minhas, Samir Mirza, Nisar Asmi, Jonathon ConstantinAbstractDonors after brain dead (DBD) have been the major source of organ donation due to good perfusion of the organs. However, due to the mismatch in demand and supply of the organ donors and recipients, organ donation after circulatory death has increased recently all over the world. Kidneys, liver and lungs are being used for transplantation from Donors after circulatory death (DCDDs). Recently, he...
Source: Indian Heart Journal - Category: Cardiology Source Type: research
CONCLUSION: Ex vivo lung perfusion can safely be used in the evaluation of lungs initially considered not suitable for transplantation. The primary outcome was not negatively affected and normothermic ex vivo lung perfusion is a useful tool to increase the usage of potentially transplantable lungs. PMID: 29976122 [PubMed - as supplied by publisher]
Source: The International Journal of Artificial Organs - Category: Transplant Surgery Authors: Tags: Int J Artif Organs Source Type: research
Donation after circulatory determination of death (DCD) is a growing source of organs in abdominal and lung transplantation but has been avoided for heart transplantation due to risks of injury associated with uncontrolled warm ischemic arrest. Ex-vivo heart perfusion with the Organ Care System (OCS) provides a unique opportunity to assess the function and metabolic profile of hearts from DCD donors. We tested the hypothesis that OCS may actually promote recovery from ischemic injury with a goal to demonstrating the feasibility of this approach for use in DCD cardiac donors in the United States.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Conclusions All the lungs showed excellent blood gases after EVLP, and they all meet the criteria's for clinical lung transplantation. The use of alteplase did not seem to have any obvious benefit to the donor lungs in a DCD situation. The donor lungs treated with alteplas showed slightly better blood gases and slightly lower PVR compared to the group without alteplas, however the difference was not significant. DCD appears to be a safe and effective method to expand the donor pool.
Source: Annals of Medicine and Surgery - Category: General Medicine Source Type: research
This study aimed to estimate associations between combined measurements of BMI and waist-to-hip ratio (WHR) with mortality and incident coronary artery disease (CAD). This study followed 130,473 UK Biobank participants aged 60-69 years (baseline 2006-2010) for 8.3 years (n = 2974 deaths). Current smokers and individuals with recent or disease-associated (e.g., from dementia, heart failure, or cancer) weight loss were excluded, yielding a "healthier agers" group. Ignoring WHR, the risk of mortality for overweight subjects was similar to that for normal-weight subjects. However, among normal-weight subjects...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
We report thirteen hours of ex-vivo perfusion of a DCD donor heart as a proof-of-concept that long-term preservation and treatment of organs is feasible.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Heart transplantation is limited by the scarcity of suitable donor organs. A few transplant teams have used hearts following donation after circulatory determined death (DCD) with ex-situ organ perfusion to address this unmet need. Clinical outcomes following DCD transplantation have been promising, however patterns of ischaemic reperfusion injury (IRI) and rejection post-transplant in clinical practice have not yet been reported.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Abstract In transplantation surgery, extending the criteria for organ donation to include organs that may have otherwise been previously discarded has provided the impetus to improve organ preservation. The traditional method of cold static storage (CS) has been tried and tested and is suitable for organs meeting standard criteria donation. Ex vivo machine perfusion is, however, associated with evidence suggesting that it may be better than CS alone and may allow for organ donation criteria to be extended. Much of our knowledge of organ preservation is derived from animal studies. We review ex vivo porcine organ perfusion ...
Source: Artificial Organs - Category: Transplant Surgery Authors: Tags: Main Text Source Type: research
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Source: American Journal of Transplantation - Category: Transplant Surgery Authors: Tags: Original Article Source Type: research
This study included 647 patients 80 to 106 years of age who had audiometric evaluations at an academic medical center (141 had multiple audiograms). The degree of hearing loss was compared across the following age brackets: 80 to 84 years, 85 to 89 years, 90 to 94 years, and 95 years and older. From an individual perspective, the rate of hearing decrease between 2 audiograms was compared with age. The researchers found that changes in hearing among age brackets were higher during the 10th decade of life than the 9th decade at all frequencies for all the patients (average age, 90 years). Correspondingly, the annual rate of ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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