Trajectories of plasma IGF-1, IGFBP-3, and their ratio in the Mayo Clinic Study of Aging.

We examined baseline and serial measures of plasma total IGF-1, IGF binding protein (IGFBP)-3, and their ratio, which is a proxy for bioavailable IGF-1, among 1618 adults, aged 50-95, enrolled in the Mayo Clinic Study of Aging. At baseline, IGF-1 and IGFBP-3 were strongly correlated (r = 0.62, p 
Source: Experimental Gerontology - Category: Geriatrics Authors: Tags: Exp Gerontol Source Type: research

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Publication date: July 2018Source: American Journal of Preventive Medicine, Volume 55, Issue 1Author(s): Glen B. Taksler, Elizabeth R. Pfoh, Kurt C. Stange, Michael B. RothbergIntroductionThe number of preventive care guidelines is rapidly increasing. It is unknown whether the number of guideline-recommended preventive services is associated with utilization.MethodsThe authors used Poisson regression of 390,778 person-years of electronic medical records data from 2008 to 2015, in 80,773 individuals aged 50–75 years. Analyses considered eligibility for 11 preventive services most closely associated with guidelines: to...
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
ConclusionThis study underlines the relevance of a systematic screening of multimorbidities in chronic inflammatory rheumatic diseases and its feasibility in a 1-day clinic. Spirometry and sleep apnea screening should be added to EULAR points to consider. The long-term impact of such screening needs to be evaluated.
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research
Publication date: July 2018Source: American Journal of Preventive Medicine, Volume 55, Issue 1Author(s): Glen B. Taksler, Elizabeth R. Pfoh, Kurt C. Stange, Michael B. RothbergIntroductionThe number of preventive care guidelines is rapidly increasing. It is unknown whether the number of guideline-recommended preventive services is associated with utilization.MethodsThe authors used Poisson regression of 390,778 person-years of electronic medical records data from 2008 to 2015, in 80,773 individuals aged 50–75 years. Analyses considered eligibility for 11 preventive services most closely associated with guidelines: to...
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
ConclusionThis study underlines the relevance of a systematic screening of multimorbidities in chronic inflammatory rheumatic diseases and its feasibility in a 1-day clinic. Spirometry and sleep apnea screening should be added to EULAR points to consider. The long-term impact of such screening needs to be evaluated.
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Recent (and not yet fully accepted) evidence suggests that chimpanzees and dolphins might suffer Alzheimer's disease, or at least a condition that is similar enough to be comparable. Other than possibly those two species, humans are the only mammals to experience Alzheimer's, the aggregation of amyloid-β and tau proteins into solid deposits that alter brain biochemistry for the worse. Why is this the case? What is it about our particular evolutionary path that resulted in this outcome? Might that teach us anything that could be used to suppress the development of the condition? In this article, Alzheimer's is p...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
ges E. Haddad Alcohol abuse can affect more than the heart and the liver. Many observers often do not appreciate the complex and differing aspects of alcohol’s effects in pathophysiologies that have been reported in multiple organs. Chronic alcohol abuse is known to be associated with pathophysiological changes that often result in life-threatening clinical outcomes, e.g., breast and colon cancer, pancreatic disease, cirrhosis of the liver, diabetes, osteoporosis, arthritis, kidney disease, immune system dysfunction, hypertension, coronary artery disease, cardiomyopathy, and can be as far-reaching as to cause...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Review Source Type: research
Conclusions The rate of preventive care utilization was lower when the number of guideline-recommended services was higher. Prioritizing recommendations might improve utilization of high-value services.
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Restoration of vitamin D is one of the most powerful health strategies to have come along in years. Combine this with other Wheat Belly strategies and you have an exceptionally effective way to reverse the factors that allow numerous modern health conditions such as diabetes (type 1 and 2), hypertension, bone thinning, arthritis, depression, and autoimmune diseases. Vitamin D is such a crucial factor in health that you would therefore think that most doctors would be experts in vitamin D. Sadly, that is not the case. The majority of mainstream medical doctors are woefully ignorant, do not read the science nor try to unders...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Undoctored Wheat Belly Lifestyle autoimmune calcium Inflammation vitamin D Wheat Belly Total Health Source Type: blogs
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