Trajectories of plasma IGF-1, IGFBP-3, and their ratio in the Mayo Clinic Study of Aging.

We examined baseline and serial measures of plasma total IGF-1, IGF binding protein (IGFBP)-3, and their ratio, which is a proxy for bioavailable IGF-1, among 1618 adults, aged 50-95, enrolled in the Mayo Clinic Study of Aging. At baseline, IGF-1 and IGFBP-3 were strongly correlated (r = 0.62, p 
Source: Experimental Gerontology - Category: Geriatrics Authors: Tags: Exp Gerontol Source Type: research

Related Links:

This article, unfortunately paywalled, is interesting to note as a mark of the now increasingly energetic expansion of commercial efforts in longevity science. David Sinclair has been building a private equity company to work in many areas relevant to this present generation of commercial longevity science; while I'm not sold on his primary research interests as the basis for meaningful treatments for aging, he is diversifying considerably here, including into senolytics, the clearance of senescent cells demonstrated to produce rejuvenation in animal studies. This sort of approach to business mixes aspects of investing and...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
By Tara John (CNN) — Vitamin D supplements do not improve bone mineral density or prevent fractures or falls in adults, finds a large study that advises health professionals to stop recommending the supplements to most patients. The vitamin has long been associated with a decreased risk of a number of conditions, such as osteoporosis and hypertension, in addition to keeping bones strong by helping the body absorb calcium — which is why many use it during the dark winter months. But the study’s authors say there is “little justification” in doing so when it comes to bone health. “Our meta...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News Bone health CNN Vitamin D Source Type: news
In this study, we found that TXNIP deficiency induces accelerated senescent phenotypes of mouse embryonic fibroblast (MEF) cells under high glucose condition and that the induction of cellular ROS or AKT activation is critical for cellular senescence. Our results also revealed that TXNIP inhibits AKT activity by a direct interaction, which is upregulated by high glucose and H2O2 treatment. In addition, TXNIP knockout mice exhibited an increase in glucose uptake and aging-associated phenotypes including a decrease in energy metabolism and induction of cellular senescence and aging-associated gene expression. We propose that...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
(Natural News) Only in America is every single disease and disorder diagnosed by medical doctors as genetic, meaning inherited from your parents’ and grandparents’ genes, even though nearly all of the most popular chronic illnesses, like cancer, diabetes, heart disease, high blood pressure, high cholesterol, strokes, arthritis, osteoporosis, Alzheimer’s, and Parkinson’s barely existed just one...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Publication date: July 2018Source: American Journal of Preventive Medicine, Volume 55, Issue 1Author(s): Glen B. Taksler, Elizabeth R. Pfoh, Kurt C. Stange, Michael B. RothbergIntroductionThe number of preventive care guidelines is rapidly increasing. It is unknown whether the number of guideline-recommended preventive services is associated with utilization.MethodsThe authors used Poisson regression of 390,778 person-years of electronic medical records data from 2008 to 2015, in 80,773 individuals aged 50–75 years. Analyses considered eligibility for 11 preventive services most closely associated with guidelines: to...
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
ConclusionThis study underlines the relevance of a systematic screening of multimorbidities in chronic inflammatory rheumatic diseases and its feasibility in a 1-day clinic. Spirometry and sleep apnea screening should be added to EULAR points to consider. The long-term impact of such screening needs to be evaluated.
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research
Publication date: July 2018Source: American Journal of Preventive Medicine, Volume 55, Issue 1Author(s): Glen B. Taksler, Elizabeth R. Pfoh, Kurt C. Stange, Michael B. RothbergIntroductionThe number of preventive care guidelines is rapidly increasing. It is unknown whether the number of guideline-recommended preventive services is associated with utilization.MethodsThe authors used Poisson regression of 390,778 person-years of electronic medical records data from 2008 to 2015, in 80,773 individuals aged 50–75 years. Analyses considered eligibility for 11 preventive services most closely associated with guidelines: to...
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
ConclusionThis study underlines the relevance of a systematic screening of multimorbidities in chronic inflammatory rheumatic diseases and its feasibility in a 1-day clinic. Spirometry and sleep apnea screening should be added to EULAR points to consider. The long-term impact of such screening needs to be evaluated.
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
More News: Brain | Cancer | Cancer & Oncology | Cardiology | Cardiovascular | Diabetes | Endocrinology | Geriatrics | Heart | Hormone Replacement Therapy | Hormones | Hypertension | Insulin | Neurology | Orthopaedics | Osteoporosis | Study | Women