The Role of LRRK2 in Neurodegeneration of Parkinson Disease.

The Role of LRRK2 in Neurodegeneration of Parkinson Disease. Curr Neuropharmacol. 2018 Feb 22;: Authors: Rui Q, Ni H, Li D, Gao R, Chen G Abstract The leucine-rich repeat kinase 2 (LRRK2) gene and α-synuclein gene (SNCA) are the key influence factors of Parkinson's disease (PD). It is reported that dysfunction of LRRK2 may influence the accumulation of α-synuclein and its pathology to alter cellular functions and signaling pathways by the kinase activation of LRRK2. The accumulation of α-synuclein is one of the main stimulants of microglias acitiviton. Microglias are macrophages resided in the brain, and activation of microglials is believed to contribute to neuroinflammation and neuronal death in PD. Therefore, clarifying the complex relation among LRRK2, α-synuclein and microglials could offer targeted clinical therapies for PD. Here, we provide an update review focused discussion of the evidence supporting some of the key mechanisms that are important for LRRK2-dependent neurodegeneration in PD. PMID: 29473513 [PubMed - as supplied by publisher]
Source: Current Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Neuropharmacol Source Type: research

Related Links:

Inflammation has been found to be associated with many neurodegenerative diseases, including Parkinson ’s and dementia. Attenuation of microglia-induced inflammation is a strategy that impedes the progression o...
Source: BMC Complementary and Alternative Medicine - Category: Complementary Medicine Authors: Tags: Research article Source Type: research
Condition:   Parkinson Intervention:   Device: DBS Sponsors:   St. Jude Medical;   Baylor College of Medicine;   University of Houston Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 14 August 2018Source: Neurochemistry InternationalAuthor(s): Lindsay Joy Spielman, Deanna Lynn Gibson, Andis KlegerisAbstractThe number of bacterial cells living within the human body is approximately equal to, or greater than, the total number of human cells. This dynamic population of microorganisms, termed the human microbiota, resides mainly within the gastrointestinal tract. It is widely accepted that highly diverse and stable microbiota promote overall human health. Colonization of the gut with maladaptive and pathogenic microbiota, a state also known as dysbiosis, is associated wit...
Source: Neurochemistry International - Category: Neuroscience Source Type: research
Zhijiang Wang, Xiuqin Jia, Huimin Chen, Tao Feng, Huali Wang
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Analyst, 2018, Accepted Manuscript DOI: 10.1039/C8AN00804C, PaperNatalie Schwenk, Boris Mizaikoff, Soledad C árdenas, Ángela I. López-Lorente Aggregation of proteins has been related to some neurodegenerative diseases such as Alzheimer, and Parkinson among others. Raman spectroscopy is a useful technique for the investigation of protein conformation, and... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - Category: Chemistry Authors: Source Type: research
(Michigan State University) An aquarium fish that senses the Earth's magnetic field as it swims could help unlock how the human brain works and how diseases such as Parkinson's and other neurological disorders function. Michigan State University scientists are the first to discover a navigational gene in glass catfish called the electromagnetic-perceptive gene, or EPG, that responds to certain magnetic waves. They've already developed a way to use it to control movement in mice.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
(Natural News) Your health is greatly affected by the food you eat – it’s been proven time and time again. A study presented at the Fourth World Parkinson Congress builds on this fact, as they reported that eating foods commonly found in a Mediterranean diet were associated with a slower progression of Parkinson’s disease. Researchers at Bastyr University...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Journal of Oral Rehabilitation, EarlyView.
Source: Journal of Oral Rehabilitation - Category: Dentistry Authors: Source Type: research
CONCLUSIONS: The combination of neuromelanin signal and volume changes with fractional anisotropy measurements in the substantia nigra showed excellent diagnostic accuracy. Moreover, the high diagnostic accuracy of visual assessment of substantia nigra changes using dorsolateral hyperintensity analysis or neuromelanin-sensitive signal changes indicates that these techniques are promising for clinical practice.
Source: American Journal of Neuroradiology - Category: Radiology Authors: Tags: ADULT BRAIN Source Type: research
The rapid methodological development and growing availability of neuromodulation techniques have spurred myriad studies investigating their clinical effectiveness. Repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex (DLPFC) has in many instances been proven to exert antidepressant-like effects superior to placebo and equivalent to standard psychopharmacological treatment. Due to the similar neuroanatomy and neurophysiology of executive and affective control processes, rTMS to the DLPFC may be able to address multiple issues simultaneously.
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Tags: Review Article Source Type: research
More News: Brain | Drugs & Pharmacology | Genetics | Neurology | Parkinson's Disease | Pathology