The Role of LRRK2 in Neurodegeneration of Parkinson Disease.

The Role of LRRK2 in Neurodegeneration of Parkinson Disease.
Curr Neuropharmacol. 2018 Feb 22;:
Authors: Rui Q, Ni H, Li D, Gao R, Chen G
Abstract
The leucine-rich repeat kinase 2 (LRRK2) gene and α-synuclein gene (SNCA) are the key influence factors of Parkinson's disease (PD). It is reported that dysfunction of LRRK2 may influence the accumulation of α-synuclein and its pathology to alter cellular functions and signaling pathways by the kinase activation of LRRK2. The accumulation of α-synuclein is one of the main stimulants of microglias acitiviton. Microglias are macrophages resided in the brain, and activation of microglials is believed to contribute to neuroinflammation and neuronal death in PD. Therefore, clarifying the complex relation among LRRK2, α-synuclein and microglials could offer targeted clinical therapies for PD. Here, we provide an update review focused discussion of the evidence supporting some of the key mechanisms that are important for LRRK2-dependent neurodegeneration in PD.
PMID: 29473513 [PubMed - as supplied by publisher]

Source: Current Neuropharmacology - February 22, 2018 Category: Drugs & Pharmacology Authors: Rui Q, Ni H, Li D, Gao R, Chen G Tags: Curr Neuropharmacol Source Type: research