The Role of LRRK2 in Neurodegeneration of Parkinson Disease.

The Role of LRRK2 in Neurodegeneration of Parkinson Disease. Curr Neuropharmacol. 2018 Feb 22;: Authors: Rui Q, Ni H, Li D, Gao R, Chen G Abstract The leucine-rich repeat kinase 2 (LRRK2) gene and α-synuclein gene (SNCA) are the key influence factors of Parkinson's disease (PD). It is reported that dysfunction of LRRK2 may influence the accumulation of α-synuclein and its pathology to alter cellular functions and signaling pathways by the kinase activation of LRRK2. The accumulation of α-synuclein is one of the main stimulants of microglias acitiviton. Microglias are macrophages resided in the brain, and activation of microglials is believed to contribute to neuroinflammation and neuronal death in PD. Therefore, clarifying the complex relation among LRRK2, α-synuclein and microglials could offer targeted clinical therapies for PD. Here, we provide an update review focused discussion of the evidence supporting some of the key mechanisms that are important for LRRK2-dependent neurodegeneration in PD. PMID: 29473513 [PubMed - as supplied by publisher]
Source: Current Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Neuropharmacol Source Type: research

Related Links:

Source: Arquivos de Neuro-Psiquiatria - Category: Neurology Source Type: research
ABSTRACT Mutations of the GBA gene have been reported in patients with Parkinson's disease (PD) from a number of different countries, including Brazil. In order to confirm this pattern in a sample of PD patients from northern Brazil, we conducted a case-control study of the occurrence of the two most common mutations of the GBA gene (c.1226A>G; p.N370S and c.1448T>C; p.L444P) in a group of 81 PD patients and 81 control individuals, using PCR-RFLP, confirmed by the direct sequencing of the PCR products. In the patient group, three patients (3.7%) were heterozygous for the GBA c.1226A>G; p.N370S mutation, and three ...
Source: Arquivos de Neuro-Psiquiatria - Category: Neurology Source Type: research
Conditions:   Aging Disorder;   Parkinson Disease Intervention:   Other: Metrology of motor behavior Sponsors:   Central Hospital, Nancy, France;   OHS - Office d'Hygiène Sociale;   ONPA - Office Nancéien des Personnes Agées;   University of Lorraine Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The authors present their experiences with an alternative anesthesia technique for deep brain stimulation surgery for Parkinson's disease patients who cannot tolerate conscious sedation.BMC Anesthesiology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Anesthesiology Journal Article Source Type: news
ConclusionsPatients with manganism had severe bradykinesia and balance disturbances, but only slight postural tremor. In contrast, PD patients had significant postural tremor and bradykinesia, but only slight balance disturbances. Their neurobehavioral performance indicated lateralized impairment, more unilateral. Neurobehavioral performance deteriorated slightly in manganism patients during a 65-month follow-up.
Source: International Archives of Occupational and Environmental Health - Category: Occupational Health Source Type: research
CONCLUSIONS This is the first study documenting the presence of silent cerebral infarcts after WPW ablation. Further investigations are needed to evaluate the risk of silent cerebral infarcts associated with L-AP ablation. PMID: 30778023 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Condition:   Parkinson's Disease Intervention:   Diagnostic Test: genetic diagnosis Sponsor:   Zhujiang Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionsOur meta-analyses identify gray matter atrophy of the midbrain and white matter atrophy of the cerebral/cerebellar pedunculi and midbrain as characteristic for PSP. Results support the incorporation of structural MRI data, and particularly these structures, into the revised PSP diagnostic criteria.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Sellers of such " young blood " plasma transfusions have claimed that they can " treat " normal aging, memory loss, dementia, Parkinson ’s disease, multiple sclerosis, heart disease, or post-traumatic stress disorder.
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Source Type: news
Sellers of such " young blood " plasma transfusions have claimed that they can " treat " normal aging, memory loss, dementia, Parkinson ’s disease, multiple sclerosis, heart disease, or post-traumatic stress disorder.
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Source Type: news
More News: Brain | Drugs & Pharmacology | Genetics | Neurology | Parkinson's Disease | Pathology