The Role of LRRK2 in Neurodegeneration of Parkinson Disease.
The Role of LRRK2 in Neurodegeneration of Parkinson Disease. Curr Neuropharmacol. 2018 Feb 22;: Authors: Rui Q, Ni H, Li D, Gao R, Chen G Abstract The leucine-rich repeat kinase 2 (LRRK2) gene and α-synuclein gene (SNCA) are the key influence factors of Parkinson's disease (PD). It is reported that dysfunction of LRRK2 may influence the accumulation of α-synuclein and its pathology to alter cellular functions and signaling pathways by the kinase activation of LRRK2. The accumulation of α-synuclein is one of the main stimulants of microglias acitiviton. Microglias are macrophages resided in the brain, and activation of microglials is believed to contribute to neuroinflammation and neuronal death in PD. Therefore, clarifying the complex relation among LRRK2, α-synuclein and microglials could offer targeted clinical therapies for PD. Here, we provide an update review focused discussion of the evidence supporting some of the key mechanisms that are important for LRRK2-dependent neurodegeneration in PD. PMID: 29473513 [PubMed - as supplied by publisher]
PARKINSON ’S disease symptoms develop gradually over a period of time, and could be caused by nerve damage in the brain. These are the most common warning signs and symptoms of the neurodegenerative condition - does your handwriting look like this?
The Parkinson's Kinetigraph measures movements and assesses medication compliance in the home setting. It has provided data that have changed patient management in a third of cases, a trial shows.Medscape Medical News
ConclusionWe describe the use of a processing pipeline to aid clinicians and researchers engaged in deep brain stimulation work to correlate and visualize the intraoperative recording data with the post-operative DBS trajectory.
Dementia affects half of Parkinson disease patients within a decade of diagnosis. Can neuroimaging detect early signs of cognitive involvement?Brain
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.8b00426
In the original publication of this article, the author Magarida Rodrigues was written incorrectly.
Pain is common in Parkinson's disease, but peripheral factors may not be to blame. Central factors are an important cause of pain so may require centrally acting drugs, a large study suggests.Medscape Medical News
Ruwani S. Wijeyekoon, Deborah Kronenberg-Versteeg, Kirsten M. Scott, Shaista Hayat, Joanne L. Jones, Menna R. Clatworthy, R. Andres Floto, Roger A. Barker, Caroline H. Williams-Gray
PARKINSON ’S disease symptoms develop slowly over a long period of time, and could be caused by nerve damage in the brain. These are the most common warning signs and symptoms of the neurodegenerative condition - can you hear this sound in your voice when you talk?
Condition: Parkinson Disease Intervention: Sponsors: Rush University Medical Center; California Institute of Technology; Purdue University Recruiting