Targeting CD6 for the treatment of experimental autoimmune uveitis.

CONCLUSIONS: Together, these data strongly suggest that CD6 plays a previously unknown, but pivotal role in autoimmune uveitis, and may be a promising new treatment target for this blinding disease. In addition, the newly developed mouse anti-mouse/human CD6 mAbs could be valuable tools for testing CD6-targeted therapies in other mouse models of human diseases.
PMID: 29472120 [PubMed - as supplied by publisher]

Source: Journal of Autoimmunity - February 19, 2018 Category: Allergy & Immunology Authors: Zhang L, Li Y, Qiu W, Bell BA, Dvorina N, Baldwin WM, Singer N, Kern T, Caspi RR, Fox DA, Lin F Tags: J Autoimmun Source Type: research