GSE111069 Patterns of IgH rearrangement stratify prognosis of diffuse large B-cell lymphoma, which could be associated with CDC25A

Contributors : Tetsumi Yoshida ; Keichiro Mihara ; Megu Ohtaki ; Yoshinori Ohno ; Yoshihiro Takihara ; Noriyuki Shiroma ; Koji Arihiro ; Naomi Sasaki ; Tatsuo IchinoheSeries Type : Expression profiling by arrayOrganism : Homo sapiensOver 80% of patients with diffuse large B-cell lymphoma (DLBCL) treated with R-CHOP achieve complete remission with variable 5-year overall survival (OS) rates of 60 to 70% depending on the preexisting risk factors. We herein attempted to stratify DLBCL by the patterns of immunoglobulin heavy chain gene rearrangement (IgH-R) by using a PCR-based clonality detection method to predict prognosis of the patients with DLBCL. We retrospectively analyzed 81 patients with DLBCL who were treated at our hospital from 2006 to 2013 and had data on IgH-R of lymphoma cells at diagnosis. IgH-R analyses identified a uniform pattern of IgH-R harboring all frame regions (FR)1-3 not completely involving DH1-7 in 15 out of 26 patients, who failed to obtain complete remission (CR). Moreover, CR rate was quite low ((7/22 (32%)) in these patients with this IgH-R pattern. We evaluated prognostic parameters of these patients with special reference to patterns of IgH-R by univariate and multivariate proportional-hazard model. Multivariate analysis revealed that IgH-R in all FR1-3 without entire DH1-7 was significantly associated with adverse overall survival. Then, gene expression profiling of mRNA elicited the candidate genes associated with poorer prognosis stra...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
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