Detection of TR34/L98H Cyp51A mutation through passive surveillance for azole-resistant Aspergillus fumigatus in the US, 2015-2017.

Detection of TR34/L98H Cyp51A mutation through passive surveillance for azole-resistant Aspergillus fumigatus in the US, 2015-2017.
Antimicrob Agents Chemother. 2018 Feb 20;:
Authors: Berkow EL, Nunnally NS, Bandea A, Kuykendall R, Beer K, Lockhart SR
Abstract
Emergence of azole resistant Aspergillus fumigatus has become a clinical problem in many parts of the world. Several amino acid mutations in the azole target protein, Cyp51Ap, contribute to this resistance, with the most concerning being the environmentally-derived TR34/L98H and TR46/Y121F/T289A mutations. Here, we performed passive surveillance to assess a sample of the A. fumigatus population in the US for the presence of these mutations. We found 1.4% of those isolates to exhibit elevated MIC via broth microdilution and five of those isolates harbored the TR34/L98H mutation.
PMID: 29463545 [PubMed - as supplied by publisher]

Source: Antimicrobial Agents and Chemotherapy - February 20, 2018 Category: Microbiology Authors: Berkow EL, Nunnally NS, Bandea A, Kuykendall R, Beer K, Lockhart SR Tags: Antimicrob Agents Chemother Source Type: research