Age-related changes in choroidal vascular density of healthy subjects based on image binarization of swept-source optical coherence tomography

Purpose: To analyze the vascular density of the choroid in a healthy population using swept-source optical coherence tomography. Methods: A cross-sectional, noninterventional study. Inclusion criteria: best-corrected visual acuity between 20/20 and 20/25, spherical equivalent between ±3 diopters, no systemic or ocular diseases, and ages ranging between 3 and 85 years. One hundred and thirty-six eyes from 136 subjects were analyzed, 86 eyes (63.2%) were from male and 50 eyes (36.8%) from female subjects. The eyes were divided into different age groups to analyze the possible age-related changes. Twelve-millimeter horizontal, fovea-centered B-scans were used. Choroidal stroma and vessel area analysis involved automated segmentation and binarization using validated algorithms. Results: Mean age was 33.1 ± 24.5 years. Mean choroidal area was 0.5554 ± 0.1377 mm2. Mean stromal area was 0.2524 ± 0.0762 mm2, and mean vascular region area was 0.3029 ± 0.0893 mm2. The percentage of choroidal vascularity (vascular area/total area) was 54.40 ± 8.35%. Choroid area, vascular region, and percentage of choroidal vascular density were statistically higher in the 18-year-old group (P
Source: RETINA - Category: Opthalmology Tags: Original Study Source Type: research
More News: Eyes | PET Scan | Statistics | Study