4 ‐Hydroxynonenal‐induced GPR109A activation elicits bipolar responses, Gαi‐mediated anti‐inflammatory effects, and Gβγ–mediated cell death

CONCLUSIONS AND IMPLICATIONSThese results revealed that 4‐HNE is a strong agonist for GPR109A that induces Gαi‐dependent anti‐inflammatory and Gβγ‐dependent cell death responses. Moreover, the present study implicates that specific intracellular signaling molecules, but not GPR109A, can serve as therapeutic targets to block 4‐HNE‐induced cell death.

Source: British Journal of Pharmacology - February 23, 2018 Category: Drugs & Pharmacology Authors: Jaya Gautam, Suhrid Banskota, Sajita Shah, Jun ‐Goo Jee, Eunju Kwon, Ying Wang, Dong Young Kim, Hyun Wook Chang, Jung‐Ae Kim Tags: RESEARCH PAPER Source Type: research