Transplantation of Recombinant Vascular Endothelial Growth Factor (VEGF)189-Neural Stem Cells Downregulates Transient Receptor Potential Vanilloid 1 (TRPV1) and Improves Motor Outcome in Spinal Cord Injury.

CONCLUSIONS Recombinant VEGF-NSCs transplantation following SCI is more efficacious compared to normal NSC transplantation. This might also be related to a reduced pain in the process of recovery due to reduced TRPV1 expression. PMID: 29466323 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research

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Neuropathic pain causes severe suffering, and most patients are resistant to current therapies. A core element of neuropathic pain is the loss of inhibitory tone in the spinal cord. Previous studies have shown that foetal GABAergic neuron precursors can provide relief from pain. However, the source of these precursor cells and their multipotent status make them unsuitable for therapeutic use. Here, we extend these findings by showing, for the first time, that spinally transplanted, terminally differentiated human induced pluripotent stem cell-derived GABAergic (iGABAergic) neurons provide significant, long-term, and safe r...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
Populations with reduced sensory and motor function, such as spinal cord injury (SCI) are at increased risk of depression, anxiety, pain, and poorer quality of life (QoL). Mindfulness-Based Interventions (MBIs...
Source: BMC Neurology - Category: Neurology Authors: Tags: Research article Source Type: research
Abstract Spinal cord injury (SCI) produces both locomotor deficits and sensory dysfunction that greatly reduce the overall quality of life. Mechanisms underlying chronic pain include increased neuro-inflammation and changes in spinal processing of sensory signals, with reduced inhibitory GABAergic signaling a likely key player. Our previous research demonstrated that spinal transplantation of GABAergic neural progenitor cells (NPCs) reduced neuropathic pain while intensive locomotor training (ILT) could reduce development of pain and partially reverse already established pain behaviors. Therefore, we evaluate the ...
Source: Experimental Neurology - Category: Neurology Authors: Tags: Exp Neurol Source Type: research
Abstract Spinal cord injury (SCI) causes maladaptive changes to nociceptive synaptic circuits within the injured spinal cord. Changes also occur at remote regions including the brain stem, limbic system, cortex, and dorsal root ganglia. These maladaptive nociceptive synaptic circuits frequently cause neuronal hyperexcitability in the entire nervous system and enhance nociceptive transmission, resulting in chronic central neuropathic pain following SCI. The underlying mechanism of chronic neuropathic pain depends on the neuroanatomical structures and electrochemical communication between pre- and postsynaptic neuro...
Source: Cellular and Molecular Neurobiology - Category: Cytology Authors: Tags: Cell Mol Neurobiol Source Type: research
ConclusionApplication of HFSCS provides an effective treatment for SNI-induced persistent mechanical hyperalgesia by attenuating ERK, JNK, and p38 activation in the dorsal root ganglia and the spinal dorsal horn.
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
DiscussionThis is the first case, to our knowledge, which reports the successful use of SCS in a patient with spinal dAVF-related pain. Spinal vascular malformations, even when cured with treatment, may result in permanent spinal cord damage and engender chronic neuropathic pain for which SCS below the level of injury may be considered.
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
Ninety percent of the applications to our Maximizing Investigators’ Research Award for Early Stage Investigators (known as the ESI MIRA program) that were submitted in October are about to undergo peer review. The remaining 10% were administratively withdrawn, mostly because the research proposed fell outside the NIGMS mission. This is comparable to the proportion that was withdrawn over the past 3 years. Withdrawn applications represent a lot of wasted time and effort on the part of affected PIs and are the source of considerable frustration. So what can you do to minimize the chance of this happening to your ES...
Source: NIGMS Feedback Loop Blog - National Institute of General Medical Sciences - Category: Biomedical Science Authors: Tags: Funding Opportunities Research Administration Early Stage Investigator Funding Policies MIRA Preparing an Application Source Type: blogs
AbstractSpinal cord injury (SCI) causes temporary disabilities or permanent effects including neuropathic pain and spastiscity. The damage often results frommechanical trauma, which in turn triggers the neuroinflammatory process. Neuroinflammation plays essential roles in the structural, biochemical, and cellular changes that take place in the spinal cord after the injury. Indeed, SCI activates many different signaling pathways that coordinate the resulting cellular responses. While neuroinflammation serves as a physiological reaction to harmful stimuli, it is clear that long-lasting inflammatory response leads to aggravat...
Source: Molecular Neurobiology - Category: Neurology Source Type: research
Publication date: Available online 9 January 2020Source: Neurochemistry InternationalAuthor(s): Tasuku Nishihara, Junya Tanaka, Keisuke Sekiya, Yuki Nishikawa, Naoki Abe, Taisuke Hamada, Sakiko Kitamura, Keizo Ikemune, Shinichiro Ochi, Mohammed E. Choudhury, Hajime Yano, Toshihiro YorozuyaAbstractChronic constriction injury of the sciatic nerve is frequently considered as a cause of chronic neuropathic pain. Marked activation of microglia in the posterior horn (PH) has been well established with regard to this pain. However, microglial activation in the anterior horn (AH) is also strongly induced in this process. Therefore...
Source: Neurochemistry International - Category: Neuroscience Source Type: research
(The Physiological Society) New research shows how second-degree burns cause hard-to-treat chronic pain, and this understanding may be key to treating these complications, common in war veterans This research, published in Physiological Reports, suggests that burns cause changes to neurons in multiple parts of the spinal cord, even far from the injury site, which can contribute to chronic pain and other long-term complications.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
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