Viruses, Vol. 10, Pages 90: Oncotargeting by Vesicular Stomatitis Virus (VSV): Advances in Cancer Therapy

Viruses, Vol. 10, Pages 90: Oncotargeting by Vesicular Stomatitis Virus (VSV): Advances in Cancer Therapy Viruses doi: 10.3390/v10020090 Authors: Suman Bishnoi Ritudhwaj Tiwari Sharad Gupta Siddappa Byrareddy Debasis Nayak Modern oncotherapy approaches are based on inducing controlled apoptosis in tumor cells. Although a number of apoptosis-induction approaches are available, site-specific delivery of therapeutic agents still remain the biggest hurdle in achieving the desired cancer treatment benefit. Additionally, systemic treatment-induced toxicity remains a major limiting factor in chemotherapy. To specifically address drug-accessibility and chemotherapy side effects, oncolytic virotherapy (OV) has emerged as a novel cancer treatment alternative. In OV, recombinant viruses with higher replication capacity and stronger lytic properties are being considered for tumor cell-targeting and subsequent cell lysing. Successful application of OVs lies in achieving strict tumor-specific tropism called oncotropism, which is contingent upon the biophysical interactions of tumor cell surface receptors with viral receptors and subsequent replication of oncolytic viruses in cancer cells. In this direction, few viral vector platforms have been developed and some of these have entered pre-clinical/clinical trials. Among these, the Vesicular stomatitis virus (VSV)-based platform shows high promise, as it is not pathogenic to humans. Further, modern molecular biology technique...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research