Genome-wide association study identifies polymorphisms associated  with the analgesic effect of fentanyl in the preoperative cold pressor-induced pain test

Publication date: Available online 16 February 2018 Source:Journal of Pharmacological Sciences Author(s): Kaori Takahashi, Daisuke Nishizawa, Shinya Kasai, Yoshihiko Koukita, Ken-ichi Fukuda, Tatsuya Ichinohe, Kazutaka Ikeda Opioid analgesics are widely used for the treatment of moderate to severe pain. The analgesic effects of opioids are well known to vary among individuals. The present study focused on the genetic factors that are associated with interindividual differences in pain and opioid sensitivity. We conducted a multistage genome-wide association study in subjects who were scheduled to undergo mandibular sagittal split ramus osteotomy and were not medicated until they received fentanyl for the induction of anesthesia. We preoperatively conducted the cold pressor-induced pain test before and after fentanyl administration. The rs13093031 and rs12633508 single-nucleotide polymorphisms (SNPs) near the LOC728432 gene region and rs6961071 SNP in the tcag7.1213 gene region were significantly associated with the analgesic effect of fentanyl, based on differences in pain perception latency before and after fentanyl administration. The associations of these three SNPs that were identified in our exploratory study have not been previously reported. The two polymorphic loci (rs13093031 and rs12633508) were shown to be in strong linkage disequilibrium. Subjects with the G/G genotype of the rs13093031 and rs6961971 SNPs presented lower fentanyl-induced analgesia. Our fi...
Source: Journal of Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research