GSE80033 Somatic PRDM2 c.4459delA mutations in colorectal cancers control histone methylation and tumor growth

Contributors : Tatjana Pandzic ; Tobias Sj öblomSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPurpose: To identify the contribution of PRDM2 c.4459delA mutation to colorectal tumorigenesisMethods: We employed rAAV-mediated genome editing to correct somatic PRDM2 c.4459delA mutation in homozygously mutated cell line. Using next-generation sequencing we have compared transcriptional profile of parental and PRDM2-corrected cells.Results: RNA-seq profiling revealed that several hallmark cancer gene sets are affected by PRDM2 c.4459delA
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research