GSE98427 STAT3-initiated epigenetic activation during T helper 17 (Th17) cell differentiation is mediated by Tripartite motif containing 28

Contributors : Yu Jiang ; Huiping Lu ; Ying Liu ; Shao-cong Sun ; Wei Jin ; Xiaohu Wang ; Chen DongSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusEpigenetic regulation is important for T cell fate decision. Although STAT3 is known to initiate Th17 differentiation program, the downstream mechanism is unclear. Here we show that tripartite motif containing 28 (TRIM28) expression in Th17 cells was required for cytokine production and autoimmune diseases. Genome-wide occupancy analysis revealed that TRIM28-bound regions contained almost all Th17-specific super-enhancers, which were impaired after STAT3 or TRIM28 but not ROR t deletion. Importantly, IL6-STAT3 signaling facilitated TRIM28 binding to the Il17-Il17f locus, which was required for epigenetic activation and high-order chromosomal interaction. TRIM28 also formed a complex with STAT3 and RORt, and promoted the recruitment of RORt to target cytokine ge ne. TRIM28 thus is a key player in the epigenetic activation during T cell differentiation
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research

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