GSE99424 KH-type splicing regulatory protein (KHSRP) is involved in esophageal squamous cell carcinoma progression through regulating a subset of microRNAs

Series Type : Expression profiling by array ; Non-coding RNA profiling by arrayOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Non-coding RNA profiling by array Homo sapiens Source Type: research

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Authors: Hamamoto Y PMID: 30023126 [PubMed]
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
Authors: Cho JY, Cheung DY, Kim TJ, Kim JK Abstract Squamous papilloma is a common benign tumor of the esophagus. Patients with papilloma are usually asymptomatic, and they are diagnosed incidentally during esophagogastroduodenoscopy. Most papillomas are small and easily removed by forceps biopsy. Recurrence of papilloma after removal is rare. Human papilloma virus infection is supposed to play a role in the development of esophageal papilloma; however, malignant transformation of papilloma is extremely unusual. Here, we report a case of malignant transformation of esophageal squamous papilloma at the gastroesophag...
Source: Clinical Endoscopy - Category: Gastroenterology Tags: Clin Endosc Source Type: research
AbstractSince the early 1970s, the incidence of esophageal adenocarcinoma (EA) has increased dramatically in most Western populations while the incidence of esophageal squamous cell carcinoma has decreased. As a result, EA has become the predominant subtype of esophageal cancer in North America and Europe and is an important contributor to overall cancer mortality. Barrett ’s esophagus (BE), a metaplastic columnar epithelium of the distal esophagus, is the known precursor lesion for EA. EA and BE occur more frequently in white men over 50 years old, as well as in people with frequent symptoms of gastroesophageal...
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
In this study, we developed an integrated CRISPR interference (CRISPRi) system to selectively suppress ΔNp63 (CRISPRiΔNp63). We engineered this CRISPRi using tandemized guide RNA expression cassettes that targeted the 50 to 100 bp downstream of the transcription start site of ΔNp63 in combination with inactivated Cas9 linked to the transcription repression module Krüppel-associated box repressor domain. The plasmid vector harboring CRISPRiΔNp63 repressed ΔNp63 transcription in lung and esophageal SCC cells. Likewise, Ad-CRISPRiΔNp63, an all-in-one adenoviral vector containing the ta...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
The optimal treatment for oesophageal cancer is a matter of debate. The aim of this study was to describe patterns of care and survival in a well-defined population for squamous cell carcinoma (SCC) and adenocarcinoma (AC) of the oesophagus.
Source: Digestive and Liver Disease - Category: Gastroenterology Authors: Tags: Oncology Source Type: research
Publication date: 10 November 2018Source: Sensors and Actuators B: Chemical, Volume 273Author(s): Junbo Li, Jinghua Wang, Xinxin Zhang, Honghong Chang, Wenlong WeiAbstractGold nanoparticles (AuNPs) were modified by anti-epidermal growth factor receptor (EGFR) antibody (Ab) and EGFR aptamer (Apt) to obtain multifunctional Apt-AuNP-Ab nanoconjugate immunoprobe. The probe is specifically combined with EGFR to form large volume binding products that exhibited a remarkable enhancement of the resonance Rayleigh scattering (RRS) intensity, and to appear characteristic RRS peak at 312 nm. The scattering enhancement (Δ...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
Publication date: August 2018Source: The American Journal of Surgery, Volume 216, Issue 2Author(s): Yusuke Sato, Satoru Motoyama, Akiyuki Wakita, Yuta Kawakita, Jiajia Liu, Yushi Nagaki, Hiroshi Nanjo, Kaori Terata, Kazuhiro Imai, Hajime Saito, Yoshihiro MinamiyaAbstractBackgroundThe relationship between Toll-like receptors (TLRs) and esophageal squamous cell carcinoma (ESCC) is not completely understood.MethodsRT-qPCR was used to evaluate the mRNA expression of TLR1-10 in 13 ESCC lines. We then used ESCC tissue microarray (TMA) to confirm expression of TLR3 protein in patients with ESCC.ResultsAll ESCC lines showed 10&nda...
Source: The American Journal of Surgery - Category: Surgery Source Type: research
Authors: Zhu X, Wang J, Li L, Deng L, Wang J, Liu L, Zeng R, Wang Q, Zheng Y Abstract Although an increasing number of findings have proven that glutathione peroxidase 3 (GPX3) is methylated and down-regulated in various cancers, the underlying mechanism of its occurrence in esophageal squamous cell carcinoma (ESCC) remains unknown. In the present study, we found that the methylation rate in advanced cancers was significantly higher than that in early stage cancers by a methylation-specific polymerase chain reaction. Furthermore, the proliferation and migration capacities of KYSE-510 cells were inhibited after up-r...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
Conditions:   Clinical Stage II Esophageal Adenocarcinoma AJCC v8;   Clinical Stage II Esophageal Squamous Cell Carcinoma AJCC v8;   Clinical Stage II Gastroesophageal Junction Adenocarcinoma AJCC v8;   Clinical Stage IIA Esophageal Adenocarcinoma AJCC v8;   Clinical Stage IIA Gastroesophageal Junction Ad enocarcinoma AJCC v8;   Clinical Stage IIB Esophageal Adenocarcinoma AJCC v8;   Clinical Stage IIB Gastroesophageal Junction Adenocarcinoma AJCC v8;   Clinical Stage III Esophageal Adenocarcinoma AJCC v8;   Clinical Stage III Esophageal Squamous Cell Carcinoma AJCC v8;   C...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionThe RPA based on a clinical nomogram appears to be suitable for risk stratification in OS for resected ESCC. This practical system may help clinicians in decision making and design of clinical studies.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
More News: Cancer & Oncology | Carcinoma | Esophagus Cancer | Genetics | Skin Cancer | Squamous Cell Carcinoma