GSE99985 RNA-seq reveals abundant circRNA, lncRNA and mRNA in blood exosomes of patients with coronary heart disease
Contributor : Yuan TangSeries Type : Non-coding RNA profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensExosomes are small membrane vesicles of endocytic origin secreted by most cells, and contain a wealthy cargo of protein and RNA species that can modulate recipient cells ’ behaviors and may be used as biomarkers for diagnosis of human diseases. They have been found in blood and are valuable sources for biomarkers due to selective cargo loading and resemblance to their parental cells. The goal of this study is to identify circRNA, lncRNA and mRNA profiles in human blood by high-throughput RNA sequencing (RNA-seq). 1-4 ml plasma or serum were used to extract exosomal RNAs by exoRNeasy Serum/Plasma Maxi kit (Qiagen). The exosomal RNAs were further treated with DNAse I and subjected to ribosome minus low-input RNAseq library preparation. The libraries were seque nced by Illumina Hiseq platform.
Conclusions: The theranostic ICG/SRT@HSA-pept NMs showed great potential for the precise identification and targeted treatment of atherosclerotic diseases.
CONCLUSION: A compound heterozygous mutation of LMF1 was identified in the presenting patient with severe HTG. These findings expand on the spectrum of LMF1 mutations and contribute to the genetic diagnosis and counseling of families with HTG. PMID: 29910226 [PubMed - as supplied by publisher]
In this study we have determined the frequency and association of rs7025486 with CAD in Indians. The study was performed on 214 patients with CAD and 125 controls. The ‘AA’ genotype was associated with an increased risk in the CAD age group <50 yrs as compared to CAD age group >50 yrs (OR 3.149; P 0.034) and controls >50 yrs (OR 3.430; P 0.080). The risk allele (A) was significantly associated with premature CAD.
AbstractPurpose of the reviewCardiovascular diseases (CVDs) are the principal killers of women. In this review, we summarize data regarding CVD and mortality after hypertensive disorders of pregnancy (HDP), and highlight clinical, research and policy needs to mitigate this risk.Recent findingsRobust data indicate that women with HDP have substantially higher risk of future CVD, with a 3.7-fold increase in the risk of chronic hypertension, a 4.2-fold increase in the risk of heart failure, an 81% increase in the risk of stroke, and double the risk of atrial arrhythmias, coronary heart disease, and mortality when compared to ...
This study was conducted to evaluate the effects of probiotic supplementation on metabolic profiles in diabetic patients with coronary heart disease (CHD).
This population-based longitudinal study assesses whether an association exists between body mass index or a change in body mass index and coronary heart disease among more than 2.6 million young adults in South Korea.
CONCLUSION: Published attendance, uptake, and prescribing rates are all lower than originally anticipated, and data on impact are limited, with very few studies reporting the effect of attendance on health-related behaviours. High-quality studies comparing matched attendees and non-attendees and health economic analyses are required. PMID: 29914882 [PubMed - as supplied by publisher]
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
We read with great interest the letter to the Editor “Controversial points in the obesity paradox in patients with coronary artery disease” by Mehmet Eyuboglu . We thank the author for the interesting considerations to our recently published paper . We agree that the effect of weight loss on prognosis in patients with coronary heart disease (CHD) is heterogeneous and affected by factors in many aspects. Several major concerns have been raised by the author and will be addressed here.
This study proposed to determine if there are differences in health and health behaviors between veterans who are caregiving for others (VCOs) and veterans who are not caregiving for others (VNCOs). Materials and Methods: Data were analyzed from a population-based observational cross-section involving persons who identified as veterans in the 2009 Center for Disease Control and Prevention's (CDC) Behavioral Risk Factor Surveillance System (BRFSS) national telephone survey. Those identifying as veterans were then grouped by those who also identified as caregivers and those who did not identify as caregivers. Data were w...