KDIGO Releases CKD-MBD Guidelines, Targets PCPs, Nephrologists KDIGO Releases CKD-MBD Guidelines, Targets PCPs, Nephrologists
KDIGO released new guidelines on chronic kidney disease-mineral and bone disorder for nephrologists and primary care physicians, many of whom care for patients with chronic kidney disease themselves.Medscape Medical News
Authors: Agrawal P, Heimbruch KE, Rao S Abstract Gene expression is regulated by numerous elements including enhancers, insulators, transcription factors, and architectural proteins. Regions of DNA distal to the transcriptional start site, called enhancers, play a central role in the temporal and tissue-specific regulation of gene expression through RNA polymerase II. The identification of enhancers and other cis regulatory elements has largely been possible due to advances in next generation sequencing technologies. Enhancers regulate gene expression through chromatin loops mediated by architectural proteins such ...
ConclusionThe removal of protein-bound uremic toxins IS and pCS using DHI or salvianolic acids as protein-bound competitors is superior to previously reported strategies and drugs and may contribute to clinical hemodialysis therapeutic practice.Graphical abstract
In conclusion, we describe one novel mutation, c.1015delG, and a common mutation, c.815_816insGA, of the AGXT gene among four unrelated families with PH1. Moreover, we suggest that the short repeat of the GA dinucleotide may represent a mutation hotspot in the Chinese population. PMID: 30541997 [PubMed - in process]
In conclusion, both RH and RfH constitute challenges in clinical practice and should be addressed as distinct clinical entities by trained professionals who are capable to identify comorbidities and provide specific, diversified, and individualized treatment. PMID: 30525180 [PubMed - as supplied by publisher]
Authors: Barreto FC, Costa CRVD, Reis LMD, Custódio MR Abstract Renal osteodystrophy (ROD), a group of metabolic bone diseases secondary to chronic kidney disease (CKD), still represents a great challenge to nephrologists. Its management is tailored by the type of bone lesion - of high or low turnover - that cannot be accurately predicted by serum biomarkers of bone remodeling available in daily clinical practice, mainly parathyroid hormone (PTH) and alkaline phosphatase (AP). In view of this limitation, bone biopsy followed by bone quantitative histomorphometry, the gold-standard method for the diagnosis of...
Publication date: Available online 14 December 2018Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): Leonardo Spatola, Elena Dozio
ConclusionsMönckeberg medial calcinosis is an incidental finding on panoramic or CBCT imaging. Clinically and radiographically, its importance for the clinician is its strong association with diabetes and chronic kidney disease. The significance of Mönckeberg sclerosis of the infraorbital arteries is unknown. Radiologists and clinicians should be aware of this entity and the importance of documentation of any findings.
Authors: González Sanchidrián S, Labrador Gómez PJ, Aguilar Aguilar JC, Davin Carrero E, Gallego Domínguez S, Gómez-Martino Arroyo JR PMID: 30545713 [PubMed - as supplied by publisher]
In 1903, the German pathologist Johann M önckeberg described calcifications only affecting the tunica media of medium arteries. The entity was named Mönckeberg arteriosclerosis. Other names in the literature are Mönckeberg sclerosis and Mönckeberg medial calcinosis. The entity is strongly associated with chronic kidney disease and diab etes mellitus. Radiographically, medial calcinosis presents as areas of linear calcifications in soft tissue. The linear calcifications are described as “tram track,” “pipe stem,” “rail track,” or “tram line” when viewed longitudinally.
In conclusion, RSV could alleviate renal damage in obese mice induced by high-fat dietvia suppressing inflammation and oxidative stress.