Impaired cardiac contractile function in arginine:glycine amidinotransferase knockout mice devoid of creatine is rescued by homoarginine but not creatine

ConclusionsOur findings argue against low myocardial creatineper se as a major contributor to cardiac dysfunction. Conversely, we show that HA deficiency can impair cardiac function, which may explain why low HA is an independent risk factor for multiple cardiovascular diseases.
Source: Cardiovascular Research - Category: Cardiology Source Type: research

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Authors: Aresta C, Passeri E, Corbetta S Abstract Current primary hyperparathyroidism (PHPT) clinical presentation is asymptomatic in more than 90% of patients, while symptoms concern osteoporosis and rarely kidney stones. Here, we retrospectively investigated the prevalence of PHPT patients presenting with hypercalcemic-related symptoms (HS-PHPT) as cognitive impairment, changes in sensorium, proximal muscle weakness, nausea and vomiting, constipation, and severe dehydration, in a single center equipped with an emergency department and described their clinical features and outcome in comparison with a series of as...
Source: International Journal of Endocrinology - Category: Endocrinology Tags: Int J Endocrinol Source Type: research
We report a case of migration of arterial stent, placed in the right iliac vein into the right pulmonary artery which was diagnosed there and subsequently not removed for at least 3 years. Despite reports in the literature for the removal of migrated stents by mini-invasive interventional methods, in our case, this was not possible, because of the long period for which the foreign body was in the right pulmonary artery and the proximal partial occlusion of organized mural thrombus.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Authors: De Vecchis R, Paccone A, Di Maio M Abstract INTRODUCTION: The guidelines of the Scientific Societies of Cardiology suggest limiting water intake in the diet as one of the non-pharmacological measures for the management of chronic heart failure. However, many patients with heart failure may suffer from severe thirst, even irrespective of a possible restricted fluid intake, and this has received relatively little attention in clinical studies. Moreover, definitive and irrefutable evidence that documents the efficacy of the limitation in water consumption on major cardiovascular outcomes is lacking. Therefore...
Source: Minerva Cardioangiologica - Category: Cardiology Tags: Minerva Cardioangiol Source Type: research
CONCLUSIONS: Not all interventional procedures result in a mortality benefit. Medical therapy alone increases survival in many cardiac diseases. PMID: 32083425 [PubMed - as supplied by publisher]
Source: Minerva Cardioangiologica - Category: Cardiology Tags: Minerva Cardioangiol Source Type: research
Publication date: Available online 21 February 2020Source: American Heart JournalAuthor(s): Marat Fudim, Frederik Dalgaard, Sana M. Al-Khatib, Daniel Friedman, Kathryn Lallinger, William T. Abraham, John G.F. Cleland, Anne B. Curtis, Michael R. Gold, Valentina Kutyifa, Cecilia Linde, Daniel E. Schaber, Anthony Tang, Fatima Ali-Ahmed, Sarah Goldstein, Brystana Kaufman, Robyn Fortman, J. Kelly Davis, Lurdes Y.T. Inoue, Gillian D. SandersAbstractBackgroundAlthough cardiac resynchronization therapy (CRT) is effective for some patients with heart failure and a reduced left ventricular ejection fraction (HFrEF), evidence gaps re...
Source: American Heart Journal - Category: Cardiology Source Type: research
Authors: Iking J, Klose J, Staniszewska M, Fendler W, Herrmann K, Rischpler C Abstract Inflammation after myocardial infarction (MI) has been in the focus of cardiovascular research for several years as it influences the remodelling process of the ischaemic heart and thereby critically determines the clinical outcome of the patient. Today, it is well appreciated that inflammation is a crucial necessity for the initiation of the natural wound healing process; however, excessive inflammation can have detrimental effects and might result in adverse ventricular remodelling which is associated with an increased risk of ...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research
Conclusion Overall cost was higher for patients with DM, whether or not they were admitted with acute HF due to HFrEF or HFpEF. Cost per day alive for patients with DM continued to exceed corresponding costs for patients without DM, with HFpEF patients with DM having the highest cost.
Source: Cardiovascular Endocrinology - Category: Cardiology Tags: Original Articles Source Type: research
ABSTRACTBACKGROUNDVEST did not demonstrate a significant reduction in arrhythmic death with the wearable cardioverter ‐defibrillator (WCD), but compliance with the device may have substantially affected the results. The influence of WCD compliance on outcomes has not yet been fully evaluated.METHODSUsing linear and pooled logistic models, we performed as ‐treated analyses omitting person‐time in the hospital and adjusted for correlates of WCD compliance. To assess the impact of early stopping of WCD, we performed a per‐protocol Kaplan‐Meier analysis, censoring after the last day the WCD was worn. Interactions of ...
Source: Journal of Cardiovascular Electrophysiology - Category: Cardiology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Contributors : Reinier A Boon ; D J TrembinskiSeries Type : Expression profiling by arrayOrganism : Homo sapiensLong non-coding RNAs (lncRNAs) contribute to (patho)physiological processes in the heart. Aging is the major risk factor for cardiovascular disease and cardiomyocyte apoptosis is an underlying cause for age-related cardiac dysfunction. RNA sequencing of cardiomyocytes from young and aged mouse hearts revealed several aging-regulated lncRNAs. An siRNA screen for caspase activity identified the aging-regulated lncRNA Sarrah (ENSMUST00000140003) as anti-apoptotic, which we confirmed in human cells (human SARRAH is a...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Abstract The oxygen uptake (V˙O2) kinetics during onset of and recovery from exercise have been shown to provide valuable parameters regarding functional capacity of both chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF) patients. To investigate the influence of comorbidity of COPD in patients with CHF with reduced ejection fraction on recovery from submaximal exercise, 9 CHF-COPD male patients and 10 age-, gender-, and left ventricle ejection fraction (LVEF)-matched CHF patients underwent constant-load exercise tests (CLET) at moderate and high loads. The V˙O2, heart rate (HR), and ca...
Source: Braz J Med Biol Res - Category: Research Authors: Tags: Braz J Med Biol Res Source Type: research
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