Deoxycorticosterone acetate-salt hypertension activates placental growth factor in the spleen to couple sympathetic drive and immune system activation

ConclusionOverall, our study demonstrates that DOCA-salt requires an intact sympathetic drive to the spleen for priming of immunity and consequent BP increase. The coupling of nervous system and immune cells activation in the splenic marginal zone is established through a sympathetic-mediated PlGF release, suggesting that this pathway could be a valid therapeutic target for hypertension.
Source: Cardiovascular Research - Category: Cardiology Source Type: research

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Publication date: March 2020Source: Journal of Vascular and Interventional Radiology, Volume 31, Issue 3, SupplementAuthor(s): R. Cobb, S. Abdulla, S. Lee, N. Liss, G. Cohen, M. Gibbons, D. Yu, X. Lu
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
(Elsevier) Prematurely born babies often need oxygen therapy to prevent brain damage or death. Unfortunately, excessive oxygen can damage immature lungs and cause severe life-long problems including bronchopulmonary dysplasia (BPD) and pulmonary hypertension (PH). A new study in The American Journal of Pathology, published by Elsevier, provides insights into the important role that the hormone adrenomedullin plays in the development, recovery, and prevention of BPD and PH.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Background: Total hip arthroplasty (THA) is an effective treatment for symptomatic osteoarthritis after failed nonsurgical therapies. Minimizing perioperative complications is critical for faster recovery and shorter hospital stay. The primary aim of this study was to identify predictors of perioperative major complications (MC) and mortality after THA, and to use these predictors to develop a risk scoring system. Methods: The 2006-2016 National Surgical Quality Improvement Program (NSQIP) database was queried for adult patients who underwent primary elective THA performed under general or neuraxial anesthesia. Univar...
Source: Current Orthopaedic Practice - Category: Orthopaedics Tags: Original Research Source Type: research
According to this study: A large-scale, multinational study shows that the four first-line drug classes used to initiate monotherapy for hypertension are generally comparable.Thiazide and thiazide-like diuretics, however, had effectiveness and safety advantages over angiotensin-converting enzyme inhibitors.
Source: AJN - Category: Nursing Tags: Journal Watch Source Type: research
This study demonstrated that the DMR assay has great potential for determining the pharmacological parameters of ligands. This work may serve as guidance for other receptor and ligand assays.
Source: Journal of Pharmacological and Toxicological Methods - Category: Drugs & Pharmacology Source Type: research
Electrochemical immunosensor for the determination of the cytokine interferon gamma (IFN-γ) in saliva. Talanta. 2020 May 01;211:120761 Authors: Sánchez-Tirado E, González-Cortés A, Yáñez-Sedeño P, Pingarrón JM Abstract A simple, fast and sensitive amperometric immunosensing method for the determination of the clinically relevant cytokine interferon gamma (IFN-γ) in saliva complying the requirements demanded for this kind of sample is reported. The target analyte was sandwiched between a specific capture antibody covalently immobilized on a s...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
Abstract Methylphosphonic acid (MPn) is suspected to play an important role in aquatic systems like rivers or the open ocean. To gain more insights into the importance of MPn, e.g., for the aquatic phosphorus cycle, an analytical method for its quantitative determination was developed. The method is based on the use of an isotopically-labelled internal standard and sample preparation including solid-phase extraction (SPE). Instrumental detection was done using GC-MS after derivatisation of MPn with N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide (MTBSTFA). The study compares different isotopically-labelled co...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
European Journal of Heart Failure, EarlyView.
Source: European Journal of Heart Failure - Category: Cardiology Authors: Tags: Editorial Comment Source Type: research
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Source: News - Category: American Health Source Type: news
Macrophage-dependent impairment of α2-adrenergic autoreceptor function in sympathetic neurons from DOCA-salt but not high fat diet-induced hypertensive rats. Am J Physiol Heart Circ Physiol. 2018 Jan 05;: Authors: Mui RK, Fernandes R, Garver H, van Rooijen N, Galligan JJ Abstract DOCA-salt and obesity-related hypertension are associated with inflammation and sympathetic nervous system hyperactivity. Prejunctional α2-adrenergic receptors (α2ARs) provide negative feedback to norepinephrine release from sympathetic nerves through inhibition of N-type Ca2+ channels. Increased neuronal no...
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Tags: Am J Physiol Heart Circ Physiol Source Type: research
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