Sphingolipid Turnover Turns Over the Fate of Aneuploid Cells

Publication date: Available online 21 February 2018 Source:Trends in Genetics Author(s): Zuzana Storchová Aneuploidy, or unbalanced chromosome number, is a hallmark of cancer. Recently established model systems revealed that aneuploidy affects many aspects of cellular physiology, among them sphingolipid metabolism. The new finding that the proliferation of aneuploid cells depends on sphingolipid homeostasis offers an appealing opportunity for cancer treatment.
Source: Trends in Genetics - Category: Genetics & Stem Cells Source Type: research