MiR-1271 negatively regulates AKT/MTOR signaling and promotes apoptosis via targeting PDK1 in pancreatic cancer.

CONCLUSIONS: MiR-1271 is a potent tumor suppressor in PC, its pro-apoptotic function was partially mediated by reduced AKT/MTOR signaling. Targeting miR-1271 may represent an effective strategy for PC treatment. PMID: 29461595 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/29461595?dopt=Abstract

Source: European Review for Medical and Pharmacological Sciences - February 22, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research