Early-life stress induces cognitive disorder in middle-aged mice.

In this study, we used maternal deprivation (MD) to examine the cognitive function in middle-aged mice using a touchscreen-equipped operant chamber. In the visual-discrimination task, the aged (∼1.4 years old) control mice could accurately learn to discriminate between different visual stimuli. In contrast, the correct response rate of aged MD mice increased to ∼60% by day 10; it was still significantly lower than that of the control mice (85%). In the hippocampus of aged MD mice, the expression level of the N-methyl-d-aspartate receptor subunit GluN1 decreased significantly as compared to that in control mice. On the other hand, no significant difference in GluN1 expression level was detected in young (2.5 months old) mice. These findings indicate that early-life stress accelerates cognitive impairment in middle-aged mice. PMID: 29458841 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/29458841?dopt=Abstract

Source: Neurobiology of Aging - February 22, 2018 Category: Geriatrics Authors: Yajima H, Haijima A, Khairinisa MA, Shimokawa N, Amano I, Takatsuru Y Tags: Neurobiol Aging Source Type: research