These Antidepressants Are Most Effective, Study Says

Millions of people take antidepressants for depression. But there’s long been debate over just how effective the medications actually are. On Wednesday, a large new study provides evidence that antidepressants are more effective than placebo at treating acute depression in adults. The study, published in the journal The Lancet, looked at the published data from 522 randomized controlled trials testing 21 different types of antidepressants. The study authors also reached out to pharmaceutical companies and study authors for additional unpublished study data. All told, the data collection included 116,477 men and women, ages 18 and older, who had depression and who were treated for at least eight weeks. The researchers found that every type of antidepressant they studied was more effective at lessening symptoms of depression over time than placebo. They considered a drug “effective” if it reduced depression symptoms by 50% or more. The researchers expected to find that some antidepressants would prove to be better than placebo, but they were surprised that every drug was more effective, says lead study author Dr. Andrea Cipriani of the University of Oxford in the UK. “We were open to any result,” he says. “This is why we can say this is the final answer to the controversy.” MORE: A New Hope For Depression Though researchers found that every drug was more effective than placebo, some were more effective than others. The most effective w...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime Mental Health/Psychology Source Type: news

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ConclusionsThis study provides an initial insight into how fatigued adolescents with MDD experience CBT. Further research is required to establish whether the themes are pervasive and relatedly, how best to treat depression in fatigued adolescents receiving CBT.Practitioner points Fatigued adolescents with depression found engaging in CBT sessions and therapeutic homework demanding. Establishing a collaborative therapeutic relationship, where the therapist was perceived as genuine, appeared helpful for participation. The structured approach to therapy, combined with flexibility, was experienced as helpful. Adolescents w...
Source: Psychology and Psychotherapy: Theory, Research and Practice - Category: Psychiatry & Psychology Authors: Tags: Qualitative Paper Source Type: research
Suicidal behaviors in adolescence are a major public health concern. The dramatic rise in self-injurious behaviors among adolescents has led to an overwhelming increase in the number of those presenting to the emergency rooms. The intervention described be...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
by Friederike Kobel, Yesim Erim, Eva Morawa BackgroundWe investigated, if migration status, and additional sociodemographic and clinical factors, are associated with somatization and depressiveness at admission and with remission after inpatient psychotherapy. MethodsMultiple linear and binary logistic regression analyses were used to identify predictors for severity of somatoform and depressive symptoms at admission of inpatient psychotherapy (T0), and for remission after inpatient psychotherapy (T1). We tested the association between symptoms concerning somatization (PHQ-15: Patient-Health-Questionnaire Somatization Modu...
Source: PLoS One - Category: Biomedical Science Authors: Source Type: research
CONCLUSIONS: Our findings did not support the value of patient choice. Considering the exploratory nature of the trial, future studies designed to examine the effects of choice in depression treatment are recommended.PMID:34521212 | DOI:10.1176/appi.psychotherapy.20200042
Source: American Journal of Psychotherapy - Category: Psychiatry & Psychology Authors: Source Type: research
Prax Kinderpsychol Kinderpsychiatr. 2021 Sep;70(6):541-558. doi: 10.13109/prkk.2021.70.6.541.ABSTRACTThe manualized focused infant/toddler-parent psychotherapy fSKEPT is a psychodynamic focal treatment of early childhood regulatory disorders, in which either a conflict-related or a personality functioning-related treatment focus is carried out. The aim of the study is to review the effectiveness of fSKEPT depending on two different therapeutic treatment focuses. For this purpose, n = 81 families who received fSKEPT were examined as part of secondary analyzes of a randomized controlled study. The therapeutic treatment focus...
Source: Praxis der Kinderpsychologie und Kinderpsychiatrie - Category: Child Development Authors: Source Type: research
Electroconvulsive therapy can effectively treat depression, and is as safe as antidepressant drugs along with psychotherapy, a new analysis found.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Seizures (Medical) Mental Health and Disorders Depression (Mental) Therapy and Rehabilitation Brain Psychiatry and Psychiatrists Suicides and Suicide Attempts Memory Electroshock Therapy Source Type: news
The potential of Oxytocin (OT) as a facilitator of psychotherapy has been previously acknowledged, nonetheless, randomized controlled trials thus far have not yielded conclusive results. One approach suggested to clarify empirical inconsistencies is to refine the study hypotheses and data collection process by utilizing an in-depth idiographic exploration of the investigated phenomena. In this case illustration we provide an in-depth analysis comparing two patients hospitalized in a closed psychiatric ward with depression and undergoing psychotherapy twice a week. These two patients were randomly allocated to receive eithe...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
AbstractWriting Therapy (WT) is defined as a process of investigation about personal thoughts and feelings using the act of writing as an instrument, with the aim of promoting self-healing and personal growth. WT has been integrated in specific psychotherapies with the aim of treating specific mental disorders (PTSD, depression, etc.). More recently, WT has been included in several Positive Interventions (PI) as a useful tool to promote psychological well-being. This narrative review was conducted by searching on scientific databases and analyzing essential studies, academic books and journal articles where writing therapy...
Source: Journal of Contemporary Psychotherapy - Category: Psychiatry & Psychology Source Type: research
Dr. David Prezant was knocked fully airborne at 9:59 on the morning of Sept. 11, 2001. He didn’t see the impact coming, but he felt it when it hit—and it nearly killed him. Little more than an hour earlier, Prezant, then the deputy chief medical officer of the Fire Department of New York, was headed for his usual workplace at the FDNY’s Office of Medical Affairs, just across the Manhattan Bridge in Brooklyn. He had already heard that a plane had hit the North Tower of the World Trade Center, and he reckoned that it was an accident. By the time he reached his office, however, the South Tower had been struc...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthscienceclimate Source Type: news
We examined the associations between initial treatments and sustained response by conducting a network meta-analysis of randomized controlled trials (RCTs) in which adult patients with major depression were randomized to acute treatment with a psychotherapy (PSY), a protocolized antidepressant pharmacotherapy (PHA), their combination (COM), standard treatment in primary or secondary care (STD), or pill placebo, and were then followed up through a maintenance phase. By design, acute phase treatment could be continued into the maintenance phase, switched to another treatment or followed by discretionary treatment. We include...
Source: World Psychiatry - Category: Psychiatry Authors: Source Type: research
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