the role of mast cell-derived lipid mediators in anaphylaxis.
[THE ROLE OF MAST CELL-DERIVED LIPID MEDIATORS IN ANAPHYLAXIS]. Arerugi. 2018;67(1):31-36 Authors: Nakamura T PMID: 29459523 [PubMed - in process]
Publication date: Available online 15 February 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Samantha Platt, Scott H. Sicherer
We report a case of an 8-year-old boy who developed a cochineal allergy.Current disease history: He has been suffering from atopic dermatitis, bronchial asthma, and food allergies since childhood. At the age of seven, he experienced an unknown anaphylaxis reaction twice. When he was 8 years old, he ate a frankfurter containing hypoallergenic cochineal for the first time; cold sweat, intraoral discomfort, respiratory distress, and urticaria appeared throughout the body. His skin prick tests were positive, with a result of 2+to frankfurter and cochineal dyes (color value 0.1 and 0.01). In the immunoblot assay, binding of IgE...
CONCLUSION: These data suggest that FDEIA and post-OIT-FDEIA patients can exhibit similar clinical symptoms, and all symptoms occurred in 60 minutes after exercise. PMID: 32051367 [PubMed - in process]
ConclusionNo patient experienced adverse events directly related to gadoterate meglumine. Only two adverse events were reported to have occurred in the initial 2 h after the exam, while the rest were reported on the 24-h follow-up call. The higher reported rate of adverse events in this study may be related to concomitant sedation/anesthesia as well as to overreporting from parents on the 24-h follow-up questionnaire. The study confirms a good safety profi le for gadoterate meglumine in this very sensitive population.
PMID: 32053569 [PubMed - as supplied by publisher]
Hi team, I have a patient who has anaphylactic reaction to an IM steroid 10 years ago- details unknown but good history including ICU stay for 3 days. Do you guys have allergist that test for Depomedrol/ decadron/ Kenalog? What other options for epidural Thanks
Deaths due to food allergy are incredibly rare (1), but it is now understood that food is the most commonly identified trigger of anaphylaxis (2). In the United States, deaths from food anaphylaxis are broadly estimated to occur at a rate of 5-200 cases per year (3).
PMID: 32057931 [PubMed - as supplied by publisher]
CONCLUSIONS: VVN has become the commonest cause of Hymenoptera anaphylaxis in our area. Most cases report no previous VVN stings. Their sensitization pattern is similar to that of patients with anaphylaxis to other Vespidae. Specific IgE to antigen-5 from VVN, Vespula spp., and Polistes dominula are strongly correlated in patients with VVN anaphylaxis. PMID: 32043465 [PubMed - as supplied by publisher]
RARITAN, NJ, February 10, 2020 – The Janssen Pharmaceutical Companies of Johnson &Johnson announced today the submission of a supplemental Biologics License Application (sBLA) to the U.S. Food and Drug Administration (FDA) seeking approval of DARZALEX® (daratumumab) in combination with Kyprolis® (carfilzomib) and dexamethasone (DKd) for relapsed/refractory multiple myeloma. The sBLA is supported by results from the Phase 3 CANDOR study, which compared treatment with DKd to carfilzomib and dexamethasone (Kd) in patients with multiple myeloma who relapsed after one to three prior lines of therapy. “Wh...
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