The Role of Personality in a Regular Cognitive Monitoring Program.

This study examines the role of personality in cognitive performance, adherence, and satisfaction with regular cognitive self-monitoring. MATERIALS AND METHODS: One hundred fifty-seven cognitively healthy older adults, age 55+, completed the 44-item Big-Five Inventory and were subsequently engaged in online monthly cognitive monitoring using the Cogstate Brief Battery for up to 35 months (M=14 mo, SD=7 mo). The test measures speed and accuracy in reaction time, visual learning, and working memory tasks. RESULTS: Neuroticism, although not related to cognitive performance overall (P>0.05), was related to a greater increase in accuracy (estimate=0.07, P=0.04) and speed (estimate=-0.09, P=0.03) on One Card Learning. Greater conscientiousness was related to faster overall speed on Detection (estimate=-1.62, P=0.02) and a significant rate of improvement in speed on One Card Learning (estimate=-0.10, P
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

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With the development of rejuvenation therapies underway, and accelerating, somewhere ahead lies a dividing line. Some people will be the last to age to death, too comprehensively damaged for the technologies of the time to recover. Everyone else will live indefinitely in youth and health, protected from aging by periodic repair of the underlying cell and tissue damage that causes dysfunction and disease. Where is that dividing line? No one can say in certainty. I look at the children of today, with long lives ahead of them, and find it hard to believe that in a hundred years the problem won't be solved well in time for the...
Source: Fight Aging! - Category: Research Authors: Tags: Of Interest Source Type: blogs
Lessons from Alzheimer's Disease (AD) Clinical Trials: Instead of "A-Drug", AD-D prevention to Avert AD. Curr Alzheimer Res. 2019;16(4):279-280 Authors: Lahiri DK Abstract PMID: 31104627 [PubMed - in process]
Source: Current Alzheimer Research - Category: Neurology Authors: Tags: Curr Alzheimer Res Source Type: research
Conditions:   Alzheimer Disease;   Dementia, Alzheimer Type;   Deep Brain Stimulation Interventions:   Device: Deep brain stimulation;   Drug: Best medical treatment for Alzheimer's disease Sponsors:   Buddhist Tzu Chi General Hospital;   Beijing Tiantan Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Moderate Alzheimer's Disease Interventions:   Drug: GV1001;   Drug: Normal saline Sponsor:   GemVax & Kael Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Alzheimer Disease;   Dementia, Alzheimer Type;   Deep Brain Stimulation Interventions:   Device: Deep brain stimulation;   Drug: Best medical treatment for Alzheimer's disease Sponsors:   Buddhist Tzu Chi General Hospital;   Beijing Tiantan Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Panza F, Lozupone M, Watling M, Imbimbo BP PMID: 31112433 [PubMed - as supplied by publisher]
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research
Authors: Kuo YC, Rajesh R Abstract INTRODUCTION: Alzheimer's disease (AD), a commonly encountered neurodegenerative disorder, causes cognitive decline and has a devastating effect on quality of life. AD occurs mainly through abnormal amyloid β peptide (Aβ) and tau protein (tau) activity around/in neurons. Aβ-based therapeutic techniques have been struggled to treat AD over the past few decades. In addition, the complexity in treating AD is due to diverse factors regulating its pathology. Areas covered: This review emphasizes recent advances regarding various pathological approaches and provides an overv...
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research
It’s funny how people only start thinking about death when either a loved one has passed away, or they’re facing their own imminent mortality. But the time to talk and think about death is not at the end — but throughout your life. Because unbeknownst to you, there is an entire profession aligned against you having a good death. And that is (nearly) the entire profession of doctors. I was listening to “Fresh Air” on NPR yesterday with Terry Gross speaking to bioethicist Tia Powell about having a good death with dementia, among other topics. It made me think of my own dad’s recent death...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Death & Dying Ethics & Morality Family General Grief and Loss Policy and Advocacy Professional Source Type: blogs
Funding Opportunity RFA-AG-20-043 from the NIH Guide for Grants and Contracts. This funding opportunity will support a new, centralized infrastructure (U24) to aggregate, harmonize, manage, and share existing and future neuroimaging data collected in NIA- supported Alzheimer's Disease Research Centers (ADRCs).
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
Phys. Chem. Chem. Phys., 2019, Accepted Manuscript DOI: 10.1039/C9CP02613D, PaperShibaji Ghosh, Kalyanashis Jana, Bishwajit Ganguly Donepezil, an acetylcholinesterase inhibitor, is an approved drug for the symptomatic treatment of Alzheimer ’s disease (AD). The mechanistic pathway for the inhibition mechanism of acetylcholinesterase (AChE) by donepezil is not... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Phys. Chem. Chem. Phys. latest articles - Category: Chemistry Authors: Source Type: research
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