The Role of Personality in a Regular Cognitive Monitoring Program.

This study examines the role of personality in cognitive performance, adherence, and satisfaction with regular cognitive self-monitoring. MATERIALS AND METHODS: One hundred fifty-seven cognitively healthy older adults, age 55+, completed the 44-item Big-Five Inventory and were subsequently engaged in online monthly cognitive monitoring using the Cogstate Brief Battery for up to 35 months (M=14 mo, SD=7 mo). The test measures speed and accuracy in reaction time, visual learning, and working memory tasks. RESULTS: Neuroticism, although not related to cognitive performance overall (P>0.05), was related to a greater increase in accuracy (estimate=0.07, P=0.04) and speed (estimate=-0.09, P=0.03) on One Card Learning. Greater conscientiousness was related to faster overall speed on Detection (estimate=-1.62, P=0.02) and a significant rate of improvement in speed on One Card Learning (estimate=-0.10, P
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

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Publication date: September 2018Source: Journal of Functional Foods, Volume 48Author(s): Patrícia Martinez-Oliveira, Micaela Federizzi de Oliveira, Niége Alves, Ritiéle Pinto Coelho, Bruna Cocco Pilar, Angélica Aparecida Güllich, Deise Stroher, Aline Boligon, Jacqueline da Costa Escobar Piccoli, Pâmela Mello Carpes, Vanusa ManfrediniAbstractYacon is an Andean plant used as food and medicine; it is rich in phenolic compounds with several activities described. Thus, we investigated the neuroprotective effects of the leaves and roots of yacon in β-amyloid (Aβ)-induced neurotoxi...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Publication date: 14 September 2018Source: Journal of Molecular Biology, Volume 430, Issue 18, Part BAuthor(s): Justin Ng, Roger D. Kamm, Thorsten Wohland, Rachel S. KrautAbstractThe amyloid-beta (Aβ) peptide, commonly found in elevated levels in the brains of patients with Alzheimer's disease (AD) and in the cerebrospinal fluid of individuals presenting mild cognitive impairment, is thought to be one of the major factors resulting in the onset of AD. Although observed and studied at the molecular level for several decades, the exact disease pathology of AD is still not totally clear. One way in which Aβ is thoug...
Source: Journal of Molecular Biology - Category: Molecular Biology Source Type: research
Publication date: 14 September 2018Source: Journal of Molecular Biology, Volume 430, Issue 18, Part BAuthor(s): Martina Radli, Stefan G.D. RüdigerAbstractThe molecular chaperone Hsp90 is involved in the folding, maturation, and degradation of a large number structurally and sequentially unrelated clients, often connected to serious diseases. Elucidating the principles of how Hsp90 recognizes this large variety of substrates is essential for comprehending the mechanism of this chaperone machinery, as well as it is a prerequisite for the design of client specific drugs targeting Hsp90. Here, we discuss the recent progre...
Source: Journal of Molecular Biology - Category: Molecular Biology Source Type: research
Source: MayoClinic.com - Ask a Specialist - Category: Consumer Health News Source Type: news
The combination of chronic pain and dementia is difficult to manage. While advancing dementia can render an elder heartbreakingly vulnerable, chronic pain that can't be expressed in words by the person with dementia multiplies the difficulty of compassionate care. Since dementia can leave people unable to verbally express the fact that they are in pain, they may scream, kick or hit. Read the full article on HealthCentral about managing chronic pain with people who live with dementia: MedicareFAQ – Medicare Resource Center Support a caregiver or jump-start discussion in support groups with real stories&...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
Phosphorylation of τ-protein, a component of microtubules in brain neurons, is a key pathomorphological sign of Alzheimer’s disease. The development of this intracellular defect can be promoted by Al3+, Fe3+, and Zn2+ ions. The concentrations of these ions in the brain are considerably elevated in Alzheimer ’s disease. We performed a comparative study of phosphorylation of microtubular proteins of rat brain in the presence of Al3+, Fe3+, and Zn2+ ions in concentrations of 10-500 μM and microtubular proteins of brain of patients with Alzheimer’s disease. The most likely candidate for the role of a f...
Source: Bulletin of Experimental Biology and Medicine - Category: Biology Source Type: research
In conclusion, the P-gp expression and function were suppressed in AD condition by activating inflammatory reaction, and then causing the Aβ efflux decreased. However, upregulating P-gp could increase the Aβ efflux in further to treat AD via inhibiting the inflammatory factors expression.
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Conclusions: This study showed that retinal axonal and neuronal loss is present among collision sport athletes, with most notable differences seen in boxers. These findings are accompanied by reductions in visual function and QOL, similar to patterns observed in multiple sclerosis, Alzheimer and Parkinson diseases. Vision-based changes associated with head trauma exposure that have the potential to be detected in vivo represent a unique opportunity for further study to determine if these changes in collision sport athletes are predictive of future neurodegeneration.
Source: Journal of Neuro-Ophthalmology - Category: Opthalmology Tags: Original Contribution Source Type: research
Background: The goal of the present study was to analyze the macular microvacular network in mild cognitive impirment (MCI) and Alzheimer disease (AD). Methods: Twelve patients with AD and 19 patients with MCI were recruited together with 21 cognitively normal controls with a similar range of ages. Optical coherence tomography angiography was used to image the retinal microvascular network at the macular region, including retinal vascular network (RVN), superficial vascular plexus (SVP), and deep vascular plexus (DVP). Fractal analysis (box counting, Dbox) representing the microvascular density was performed in differ...
Source: Journal of Neuro-Ophthalmology - Category: Opthalmology Tags: Original Contribution Source Type: research
M5 Muscarinic Receptor Knockout: Deficiency of M5Rs reduces drug-seeking behavior.The five Muscarinic Acetylcholine (ACh) receptors are G-protein coupled receptors (M1R-M5R). M1R, M3R and M5R selectively couple to Gq/G11; M2R and M4R selectively couple to Gi/Go. M5R knockout mice are viable and fertile, and have no major morphological abnormalities.M5 muscarinic ACh receptors are located in the central nervous system and may contribute to the cognitive-enhancing effects of ACh. M5R knockout mice show deficits in two hippocampus-dependent cognitive tasks, and exhibit reduced cerebral blood flow in the cerebral cortex and hi...
Source: NIDDK Research Resources - Category: Endocrinology Source Type: research
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