Allele Frequencies of Two Main Metformin Transporter Genes: SLC22A1 rs628031 A>G and SLC47A1 rs2289669 G>A among the Javanese Population in Indonesia

Conclusion: The allele frequency of SLC22A1 gene rs628031 in Javanese-Indonesian population was almost the same as those found in Afro-American population as well as in other Asian populations. Similar results were obtained when the A allele frequency of SLC47A1 rs2289669 was compared to those in Chinese population. Further studies are recommended to examine the correlation between these polymorphisms and the variability of pharmacokinetic profiles as well as glycemic response to metformin and its adverse reactions.
Source: Current Pharmacogenomics and Personalized Medicine - Category: Genetics & Stem Cells Source Type: research