The effects of supplemental vitamin E on hematological parameters in a rat model of ovarian hormone deficiency

Conclusion:These findings suggest that vitamin E in the form of α-tocopherol acetate may provide protection against ovarian hormone deficiency-associated adverse changes in hematological parameters. Objective: Menopause is associated with adverse changes in hematological parameters. Although the antioxidative and anti-inflammatory properties of vitamin E have been previously demonstrated, the effects of vitamin E on hematopoietic parameters are not well-documented. This study investigated the effects of supplemental vitamin E on hematological parameters in a rat model of ovarian hormone deficiency. Methods: Twelve-month-old female Sprague-Dawley rats were either sham-operated (Sham) or ovariectomized (Ovx). Animals were randomly divided among five treatment groups (n = 12/group) as follows: Sham; Ovx; Ovx + 300, Ovx + 525, or Ovx + 750 mg/kg diet of vitamin E for 100 days. Results: Compared with Sham, ovariectomy increased leukocyte subpopulation counts including lymphocytes (2.01 × 103/mm3; 95% confidence interval [CI] 0.11, 4.03; P = 0.03), monocytes (0.35 × 103/mm3; 95% CI 0.60, 0.11; P = 0.01), neutrophils (0.72 × 103/mm3; 95% CI 0.26, 1.19; P = 0.01), eosinophils (0.07 × 103/mm3; 95% CI 0.12, 0.30; P = 0.00), and basophils (0.13 × 103/mm3; 95% CI 0.04, 0.21; P = 0.02). Medium dose (MD) (−0.26 × 103/mm3; 95% CI −0.47, −0.05; P = 0.007) and high dose (HD) (−0.22 × 103/mm3; 95% C...
Source: Menopause - Category: OBGYN Tags: Original Articles Source Type: research