Clinical impact of ulceration width, lymphovascular invasion, microscopic satellitosis, perineural invasion, and mitotic rate in patients undergoing sentinel lymph node biopsy for cutaneous melanoma: a retrospective observational study at a comprehensive cancer center

In conclusion, SLN biopsy should probably be offered if the primary tumor has LVI. MS is an adverse prognostic factor for RFS, but its influence on outcome is modest. Ulceration width predicts RFS but loses its independent prognostic significance for MSS when adjusting for currently used clinicopathological factors. In view of its impact on MSS, mitotic rate should be recorded for cutaneous invasive melanomas across all T categories. SLN biopsy should be offered if the primary tumor has LVI. MS is an adverse prognostic factor for RFS, but its influence on outcome is modest. Ulceration width predicts RFS but lost its independent prognostic significance for MSS when adjusting for other contemporary clinicopathological factors. In view of its impact on MSS, mitotic rate should be recorded for cutaneous invasive melanomas across all T categories.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002%2Fcam4.1320

Source: Cancer Medicine - February 21, 2018 Category: Cancer & Oncology Authors: Kenjiro Namikawa, Phyu P. Aung, Jeffrey E. Gershenwald, Den ái R. Milton, Victor G. Prieto Tags: Original Research Source Type: research