Cutaneous Manifestations of Reactions to Biologics

AbstractPurpose of ReviewThe goal of this paper is to review the major adverse cutaneous reactions that have been reported to the most commonly used biologics.Recent FindingsAnti-TNF agents and immune checkpoint inhibitors have significant, immune-mediated cutaneous manifestations that can necessitate discontinuation. Anti-TNF agents, IL-6 inhibitors, and IL-12/23 inhibitors can paradoxically cause psoriasis flares or unmask previously undiagnosed psoriasis. IL-17 inhibitors are unique in increasing risk forCandida infections. Benign injection site reactions, non-specific rash, cellulitis, and hypersensitivity reactions are relatively common adverse events.SummaryA wide variety of cutaneous reactions caused by biologics have been reported, ranging from benign injection site reactions to life-threatening cutaneous reactions necessitating discontinuation of the implicated biologic agent.
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research