Cutaneous Manifestations of Reactions to Biologics

AbstractPurpose of ReviewThe goal of this paper is to review the major adverse cutaneous reactions that have been reported to the most commonly used biologics.Recent FindingsAnti-TNF agents and immune checkpoint inhibitors have significant, immune-mediated cutaneous manifestations that can necessitate discontinuation. Anti-TNF agents, IL-6 inhibitors, and IL-12/23 inhibitors can paradoxically cause psoriasis flares or unmask previously undiagnosed psoriasis. IL-17 inhibitors are unique in increasing risk forCandida infections. Benign injection site reactions, non-specific rash, cellulitis, and hypersensitivity reactions are relatively common adverse events.SummaryA wide variety of cutaneous reactions caused by biologics have been reported, ranging from benign injection site reactions to life-threatening cutaneous reactions necessitating discontinuation of the implicated biologic agent.
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research

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Abstract Metals are essential components in all forms of life required for the function of nearly half of all enzymes and are critically involved in virtually all fundamental biological processes. Especially, the transition metals iron (Fe), zinc (Zn), manganese (Mn), nickel (Ni), copper (Cu) and cobalt (Co) are crucial micronutrients known to play vital roles in metabolism as well due to their unique redox properties. Metals carry out three major functions within metalloproteins: to provide structural support, to serve as enzymatic cofactors, and to mediate electron transportation. Metal ions are also involved in...
Source: Advances in Immunology - Category: Allergy & Immunology Authors: Tags: Adv Immunol Source Type: research
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Source: Respiratory Investigation - Category: Respiratory Medicine Source Type: research
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Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research
Dr. Anthony Fauci, who is the director of the National Institute of Allergy and Infectious Diseases, explains what a pandemic is and says we're nearly at the brink of one with the novel coronavirus outbreak.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
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Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research
Every year in the United States, the CDC estimates that influenza results in between 9 million – 45 million illnesses, between 140,000 – 810,000 hospitalizations, and between 12,000 – 61,000 deaths (approximately 100  – 200 being pediatric fatalities). In the United States, the immense disease burden of the flu is unparalleled with any other pathogen, but fortunately there is a vaccine and antiviral medications which help to mitigate the yearly morbidity and mortality wrought by influenza.Because the flu changes its shape every year by a process called antigenic shift&n...
Source: A Pediatrician's Blog - Category: Pediatrics Source Type: blogs
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Source: Journal of the International AIDS Society - Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research
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Source: Rhinology - Category: ENT & OMF Tags: Rhinology Source Type: research
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Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research
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Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research
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