Piezo2 channel regulates RhoA and actin cytoskeleton to promote cell mechanobiological responses [Physiology]

Actin polymerization and assembly into stress fibers (SFs) is central to many cellular processes. However, how SFs form in response to the mechanical interaction of cells with their environment is not fully understood. Here we have identified Piezo2 mechanosensitive cationic channel as a transducer of environmental physical cues into mechanobiological...

Source: Proceedings of the National Academy of Sciences - February 20, 2018 Category: Science Authors: Carlos Pardo–Pastor, Fanny Rubio–Moscardo, Marina Vogel–Gonzalez, Selma A. Serra, Alexandros Afthinos, Sanela Mrkonȷic, Olivier Destaing, Juan F. Abenza, Jose M. Fernandez–Fernandez, Xavier Trepat, Corinne Albiges–Rizo Tags: Biological Sciences Source Type: research