Cysteinyl leukotriene receptor 1 antagonism prevents experimental abdominal aortic aneurysm [Medical Sciences]
Cysteinyl-leukotrienes (cys-LTs) are 5-lipoxygenase-derived lipid mediators involved in the pathogenesis and progression of inflammatory disorders, in particular asthma. We have previously found evidence linking these mediators to increased levels of proteolytic enzymes in tissue specimens of human abdominal aortic aneurysm (AAA). Here we show that antagonism of the CysLT1 receptor...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Antonio Di Gennaro, Ana Carolina Arauȷo, Albert Busch, Hong Jin, Dick Wagsater, Emina Vorkapic, Kenneth Caidahl, Per Eriksson, Bengt Samuelsson, Lars Maegdefessel, Jesper Z. Haeggstrom Tags: Biological Sciences Source Type: research