Role of a selecting ligand in shaping the murine {gamma}{delta}-TCR repertoire [Immunology and Inflammation]
Unlike αβ-T lineage cells, where the role of ligand in intrathymic selection is well established, the role of ligand in the development of γδ-T cells remains controversial. Here we provide evidence for the role of a bona fide selecting ligand in shaping the γδ-T cell-receptor (TCR) repertoire. Reactivity of the...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Shawn P. Fahl, Francis Coffey, Lisa Kain, Payam Zarin, Roland L. Dunbrack Jr., Luc Teyton, Juan Carlos Zuniga–Pflucker, Dietmar J. Kappes, David L. Wiest Tags: Biological Sciences Source Type: research