Detection of aneuploidy in patients with cancer through amplification of long interspersed nucleotide elements (LINEs) [Genetics]

Aneuploidy is a feature of most cancer cells, and a myriad of approaches have been developed to detect it in clinical samples. We previously described primers that could be used to amplify ∼38,000 unique long interspersed nucleotide elements (LINEs) from throughout the genome. Here we have developed an approach to...

Source: Proceedings of the National Academy of Sciences - February 20, 2018 Category: Science Authors: Christopher Douville, Simeon Springer, Isaac Kinde, Joshua D. Cohen, Ralph H. Hruban, Anne Marie Lennon, Nickolas Papadopoulos, Kenneth W. Kinzler, Bert Vogelstein, Rachel Karchin Tags: Biological Sciences Source Type: research