Poldip2 is an oxygen-sensitive protein that controls PDH and {alpha}KGDH lipoylation and activation to support metabolic adaptation in hypoxia and cancer [Biochemistry]
Although the addition of the prosthetic group lipoate is essential to the activity of critical mitochondrial catabolic enzymes, its regulation is unknown. Here, we show that lipoylation of the pyruvate dehydrogenase and α-ketoglutarate dehydrogenase (αKDH) complexes is a dynamically regulated process that is inhibited under hypoxia and in cancer cells...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Felipe Paredes, Kely Sheldon, Bernard Lassegue, Holly C. Williams, Elizabeth A. Faidley, Gloria A. Benavides, Gloria Torres, Fernanda Sanhueza–Olivares, Samantha M. Yeligar, Kathy K. Griendling, Victor Darley–Usmar, Aleȷandra San Martin Tags: Biological Sciences Source Type: research