Endocytosis as a stabilizing mechanism for tissue homeostasis [Systems Biology]

Cells in tissues communicate by secreted growth factors (GF) and other signals. An important function of cell circuits is tissue homeostasis: maintaining proper balance between the amounts of different cell types. Homeostasis requires negative feedback on the GFs, to avoid a runaway situation in which cells stimulate each other and...

Source: Proceedings of the National Academy of Sciences - February 20, 2018 Category: Science Authors: Miri Adler, Avi Mayo, Xu Zhou, Ruth A. Franklin, Jeremy B. Jacox, Ruslan Medzhitov, Uri Alon Tags: PNAS Plus Source Type: research