Scleroderma renal crisis.

Scleroderma renal crisis. Saudi J Kidney Dis Transpl. 2018 Jan-Feb;29(1):221-222 Authors: Cavoli GL, Bono L, Calogera T, Giammarresi C, Li Cavoli TV, Nuara G PMID: 29456236 [PubMed - in process]
Source: Saudi Journal of Kidney Diseases and Transplantation - Category: Urology & Nephrology Authors: Tags: Saudi J Kidney Dis Transpl Source Type: research

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Conclusions: Circulating CCR2+ monocytes migrate into the inflamed colon via CCL2/CCR2 axis and differentiate into CCR2+Ly6C-F4/80+ fibrocytes, which inhibit collagen degradation and contribute to the development of colon fibrosis by the production of TIMP-1.DisclosuresMasuya: Kyowa Hakko Kirin Co., Ltd.: Research Funding. Katayama: Ono Pharmaceutical: Research Funding; Novo Nordisk: Honoraria, Research Funding; Chugai Pharma: Honoraria, Research Funding; Toyama Chemical Co: Research Funding; Sysmex: Honoraria; Mochida Pharmaceutical Co. Ltd.,: Research Funding; Bristol-Myers Squibb: Honoraria; Astellas Pharma: Honoraria, ...
Source: Blood - Category: Hematology Authors: Tags: 201. Granulocytes, Monocytes, and Macrophages: Poster III Source Type: research
Background. Diffuse cutaneous systemic sclerosis (SSc) is a multi-system chronically progressive and debilitating autoimmune connective tissue disease affecting internal organs, characterized by a dysregulated immune system and the production of autoantibodies. Patients experience progressive cumulative mortality despite currently available immunosuppressive therapies.Objective. To assess the safety and efficacy of hematopoietic stem cell transplantation (SCT) with the research question: "what is the relative effect on overall mortality in patients with SSc and internal organ involvement treated with SCT compared to t...
Source: Blood - Category: Hematology Authors: Tags: 731. Clinical Autologous Transplantation: Results: Autologous Transplantation: Clonal Hematopoiesis, Microbiota, AML, NHL, and Autoimmune Diseases Source Type: research
CONCLUSIONThis study confirms that the morbidity and mortality of ASCT for patients with autoimmune disease is similar to that for other patient groups undergoing ASCT. Patient selection should take this into consideration.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - Category: Hematology Authors: Tags: 731. Clinical Autologous Transplantation: Results: Poster III Source Type: research
BackgroundRecent progress in medicine faces more patients to iatrogenic immunosuppressive state, which increases the risk of following immunodeficiency-associated lymphoproliferative disorders (LPD), such as post-transplant lymphoproliferative disorders (PTLD) which arise after solid organ or hematopoietic stem cell transplantation (HSCT), and other lymphoid proliferations or lymphomas which arise in patients treated with immunosuppressive agents for any reasons. Methotrexate for patients with rheumatoid arthritis (RA) has been the most discussed immunosuppressive agent associated with iatrogenic LPD. Nevertheless, the num...
Source: Blood - Category: Hematology Authors: Tags: 627. Aggressive Lymphoma (Diffuse Large B-Cell and Other Aggressive B-Cell Non-Hodgkin Lymphomas)-Results from Retrospective/Observational Studies Source Type: research
We examined the incidence and prevalence of ESRD due to scleroderma in Europe and the outcomes among these patients following initiation of RRT.Study DesignRegistry study of incidence and prevalence and a matched cohort study of clinical outcomes.Setting &ParticipantsPatients represented in any of 19 renal registries that provided data to the European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) Registry between 2002 and 2013.PredictorScleroderma as the identified cause of ESRD.OutcomesIncidence and prevalence of ESRD from scleroderma. Recovery from RRT dependence, patient survival aft...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In this study, 36 people with severe scleroderma received stem-cell transplantation and were compared with 39 otherwise similar people who received a year of standard immune-suppressing medication. After 4.5 years, those assigned to receive stem-cell transplantation had improved overall survival compared with standard treatment (79% vs. 50%) less need for immune-suppressing medication (9% vs. 44%) fewer deaths related to worsening scleroderma (11% vs. 28%) more deaths related to treatment — (3% vs. 0%). These findings suggest that stem-cell transplantation may be much better than standard treatment for people with ...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Autoimmune diseases Health Skin and Hair Care Source Type: blogs
Systemic sclerosis (SSc) is a chronic systemic disorder encompassing inflammatory, vascular, and fibrotic processes. SSc is characterized by thickening of the skin (scleroderma) and distinctive involvement of multiple organs, most notably the lungs, gastrointestinal tract, heart, and kidneys [1,2]. While some patients experience an indolent course, others will suffer from devastating disease progression [3]. Immunosuppressive drugs are the backbone of treatment for patients with diffuse skin involvement or severe organ dysfunction [4].
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
Morbid obesity has been shown to increase risk of perioperative complications, delayed graft function, and mortality in kidney, liver, and lung/heart transplants. Both laparoscopic gastric bypass(LGBP) and laparoscopic sleeve gastrectomy(LSG) have been proven to be safe and efficacious in patients with end-stage kidney and liver disease of various etiologies, and are utilized to improve transplant candidacy by treating morbid obesity and associated co-morbidities, however the optimal bariatric operation for each transplant is not clear.
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Source Type: research
This study is the first to examine gastrointestinal bacterial composition in two independent groups of people with systemic sclerosis. Systemic sclerosis, also known as scleroderma, is an autoimmune disease affecting the body ’s connective tissue. It is characterized by a hardening and scarring of skin and can progress to inflammation and scarring in the organs such as kidneys, heart, lungs and gastrointestinal tract. Previous UCLA-led research  detailed a link between the disease and the imbalance in the gut microbiome and suggested that this imbalance contributed to scleroderma’s symptoms.METHODThe ...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
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