Can Alcohol Help You Live Longer? Here ’s What the Research Really Says

New research, which was presented at the American Association for the Advancement of Science’s annual conference, has found that moderate drinking is linked to a longer life. Drinking about two glasses of wine or beer a day was linked to an 18% drop in a person’s risk of early death—an even stronger effect than the life-preserving practice of exercise, according to the researchers. The results came from the 90+ Study, a research project out of the University of California Irvine’s Institute for Memory Impairments and Neurological Disorders that examines the habits of people who live to at least 90. Though the study has not yet been published in a scientific journal, it triggered a spate of booze-praising headlines. But can alcohol actually help you live longer? Researchers have gone back and forth on that question for years. Here’s what the research really says about alcohol and health. Alcohol may be linked with longevity The new study isn’t the first to link alcohol with a long life. A 2015 study of people with mild Alzheimer’s, for example, found that moderate drinkers were less likely to die during the study’s follow-up period than teetotalers. A large 2017 study also found that light and moderate drinkers were less likely to die from cardiovascular disease than those who never sipped. Red wine, in particular, is often singled out for its anti-aging benefits, usually because of a compound called resveratrol — though t...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Diet/Nutrition healthytime onetime Source Type: news

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Authors: Li T, Han J, Jia L, Hu X, Chen L, Wang Y Abstract A change in the metabolic flux of glucose from mitochondrial oxidative phosphorylation (OXPHOS) to aerobic glycolysis is regarded as one hallmark of cancer. However, the mechanisms underlying the metabolic switch between aerobic glycolysis and OXPHOS are unclear. Here we show that the M2 isoform of pyruvate kinase (PKM2), one of the rate-limiting enzymes in glycolysis, interacts with mitofusin 2 (MFN2), a key regulator of mitochondrial fusion, to promote mitochondrial fusion and OXPHOS, and attenuate glycolysis. mTOR increases the PKM2:MFN2 interaction by p...
Source: Protein and Cell - Category: Cytology Tags: Protein Cell Source Type: research
Authors: Cai WW, Hu J, Wang H, Zhu GJ, Chen S, Chen XP Abstract Coronary artery bypass grafting (CABG) is an effective scheme for treatment of myocardial ischemia. Hypoxemia is a common complication of CABG, which can affect surgical effect and prognosis and even induce multiple organ failure. To explore the clinical efficacy of bi-level positive airway pressure ventilation in the treatment of CABG-associated hypoxemia, 216 patients who were admitted to our hospital between August 2015 and April 2017 and developed CABG-associated hypoxemia were selected and randomly divided into 2 groups, an observation group (n=10...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
In conclusion, CD133 promoted the upregulation of CSC/TSC-related genes in glioma cells, while enhancing the neurosphere-forming ability and in-vivo oncogenicity. PMID: 30891998 [PubMed - as supplied by publisher]
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
Conclusions: tTGIgA were increasingly tested, while the rate of positive results decreased in recent years, possibly reflecting the impact of current alimentary trends on clinical practice. Associated autoimmune disease was frequently found in CD. High levels of tTGIgA accurately predicted CD diagnosis. WA was rarely investigated and deserves more attention, in particular in children with atopic background. WA does not seem to be associated with CD.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - Category: Allergy & Immunology Source Type: research
Conclusion: Substitution of parenteral thiamine in individuals with suspected WE is a well-established treatment regimen. However, suggestions according to guidelines vary widely. Furthermore, hardly any evidence-based recommendations exist on a more general use of thiamine as a preventative intervention in individuals with AUD. Further research is of utmost importance to raise awareness for this potentially undervalued problem.Eur Addict Res 2019;25:103 –110
Source: European Addiction Research - Category: Addiction Source Type: research
Conclusions: Lifetime cannabis use is associated with better working memory and processing speed and worse real-world functioning in the area of socially useful activities in patients with schizophrenia-related disorders. Clinicians should, therefore, be aware of it to provide patient-centred care in their daily clinical practice.Eur Addict Res 2019;25:111 –118
Source: European Addiction Research - Category: Addiction Source Type: research
In this study, several cerasome-forming lipoamino acids (CFLA) were synthesized and used as structural blocks for cerasome preparation. Pure cerasomes which contained only CFLA, and mixed cerasomes based on a mixture of CFLA with a disintegrating dipalmitoylphosphatidylcholine (DPPC) lipid were fabricated and characterized in terms of morphology, mean size, ζ-potential, stability at storage. All obtained cerasome samples were found to be much more stable at storage than conventional liposomes (120 and 10 days, respectively). The cerasomes were loaded with doxorubicin (DOX) and tested in vitro using human breast aden...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Peripheral neuropathies are the most frequent neurological complications associated with HIV, within which HIV sensory neuropathy (SN) is the most common form, which affects 30-50% of HIV/acquired immunodeficiency syndrome (AIDS) patients. HIV SN is frequently manifested with hard-to-manage pain and is often under-diagnosed and/or under-treated. Tat, trans-activator of transcription, is a key activator of HIV transcription. Despite that recent studies have highlighted the role of HIV Tat in the pathophysiology of HIV-associated neurocognitive disorders (HANDs), the involvement of HIV Tat in neuropathic pain associated with...
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
Recent studies have indicated that the spinal activity of gastrin-releasing peptide (GRP) and its receptor, GRPR, selectively modulate itching behaviors over other somatosensations including pain behaviors. Despite behavioral selectivity, how GRP acts within the spinal cord to selectively convey itch to the brain is not understood. Utilizing a novel ex vivo somatosensory preparation, retrograde labeling of spinal projection neurons, and multiphoton Ca2+ imaging, the activity of excitatory interneurons and projection neurons in the ex vivo spinal cord can be recorded in response to natural stimulation of the skin and pharma...
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
Abdominal pain and bowel dysmotility are hallmark symptoms of functional bowel disorders, yet it is unclear how pain and dysmotility are correlated mechanistically. Extrinsic colon afferents (EPANs) provide sensory input to the CNS, and visceral pain is thought to be due to hypersensitivity of these afferents. The enteric nervous system (ENS) acts autonomously to control motility reflexes, but extrinsic nerve pathways coordinate activity between distant regions of the GI tract, and importantly, allow the central nervous system (CNS) to regulate GI functioning.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
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