Role of PTPN2/22 polymorphisms in pathophysiology of Crohn's disease.

CONCLUSION: The data suggests that SNPs in PTPN2/22 affect the negative regulation of the immune response in CD patients, thus leading to an increase in inflammation/apoptosis and susceptibility of mycobacteria.
PMID: 29456405 [PubMed - in process]

Source: World Journal of Gastroenterology : WJG - February 14, 2018 Category: Gastroenterology Authors: Sharp RC, Beg SA, Naser SA Tags: World J Gastroenterol Source Type: research