Safety of Tiotropium in Children with Persistent Asthma
Results of the first study to evaluate use of the adult COPD drug in children age 5 years and younger lay fertile ground for future trials.
The digital respiratory health company says this deal and clearance now give it access to 90% of the U.S. asthma and COPD market.
The potential detrimental effects of steroids on the immune system to fight viral infections had always been a concern for patients on long term steroids in chronic conditions. A recent warning from WHO on systemic corticosteroid use amid COVID-19 raised suspicion among public and healthcare professionals regarding the safety of steroid use during the SARS-CoV-2 pandemic. The corticosteroids (inhaled and oral) are commonly prescribed in the management of asthma and COPD patients and any unsolicited changes in medications use may lead to potentially severe exacerbations and risk patient lives.
WOODLAND HILLS, Calif., May 25, 2020 -- (Healthcare Sales &Marketing Network) -- 4DMedical, an Australian medical technology company specializing in medical imaging innovation software, announced today it has received clearance from the U.S. Food &Drug ... Diagnostics, Radiology, FDA 4DMedical, COVID-19, asthma, COPD, cystic fibrosis, lung cancer
In conclusion, our results suggest a previously unknown mechanism whereby the canonical NF-κB cascade and a mitochondrial fission pathway interdependently regulate endothelial inflammation. Lin28 as a Target for Nerve Regeneration https://www.fightaging.org/archives/2020/05/lin28-as-a-target-for-nerve-regeneration/ Researchers here show that the gene Lin28 regulates axon regrowth. In mice, raised levels of Lin28 produce greater regeneration of nerve injuries. Past research has investigated Lin28 from the standpoint of producing a more general improvement in regenerative capacity. It improves mitoch...
Conclusion: We conclude that acute, short-term SHS exposure had a statistically significant effect on spirometry in female asthma patients but did not significantly modify spirometric indices 24 h later in COPD patients. PMID: 32441557 [PubMed - as supplied by publisher]
Asthma-COPD overlap (ACO) refers to a group of poorly studied and characterised patients reporting with disease presentations of both asthma and COPD, thereby making both diagnosis and treatment challenging fo...
Conclusions The risk for cardiovascular disease in people with severe high-level spinal cord injury is a major clinical concern. Forthcoming studies in the SPICA will provide new knowledge of cardiopulmonary health in this cohort, which can guide future research and be used to develop long-term management.
In this study we describe a single-step, highly efficient and easily scalable genome editing pipeline to aid the dissection of the molecular mechanisms underlying primary human bronchial epithelial cell (BEC) differentiation and function at air–liquid interface (ALI).
Long-acting bronchodilators are the basis of treatment for COPD ; however, there are some patients who suffer from frequent or severe exacerbations, despite maximal bronchodilation . These patients are at increased risk of death and represent a great challenge in clinical practice . Inhaled corticosteroids (ICS) are the basis of the treatment of asthma and are also effective, albeit to a lesser extent, in some patients with COPD . Generally speaking, ICS are indicated in patients with COPD and exacerbations, despite bronchodilator treatment .
Today's open access paper is a review of what is known of the role of cellular senescence in lung disease. With the development of senolytic therapies that can selectively destroy senescent cells, all conditions in which senescent cells contribute meaningfully to pathology may soon be effectively treated. Senescent cells accumulate with age in all tissues, and while never a sizable fraction of all cells, even a comparatively small number of senescent cells can cause chronic inflammation and tissue dysfunction. They secrete a mix of inflammatory signals, growth factors, and other molecules that has a sizable effect on the b...