Mutagenicity and genotoxicity studies of aspartame

Publication date: Available online 19 February 2018 Source:Regulatory Toxicology and Pharmacology Author(s): Akira Otabe, Fumio Ohta, Asuka Takumi, Barry Lynch Two studies were conducted to further assess its mutagenic and genotoxic potential. In a bacterial reverse mutation pre-incubation study, Salmonella typhimurium strains TA100, TA1535, TA98, and TA1537 and Escherichia coli WP2 uvrA were treated with aspartame at concentrations of up to 5000 μg/plate with or without metabolic activation and showed no mutagenic potential. Similarly, in vivo micronucleus testing of aspartame following gavage administration (500–2000 mg/kg body weight) to Crlj:CD1(ICR) strain SPF male mice showed no increase in the proportion of micronucleated polychromatic erythrocytes in bone marrow cells collected and evaluated 24 or 48 h post administration. Overall, aspartame had no potential for mutagenic or genotoxic activity.
Source: Regulatory Toxicology and Pharmacology - Category: Toxicology Source Type: research