The Fondaparinux paradox: Fondaparinux-related heparin-induced thrombocytopenia

Sonali Vadi, Vishal PeshattiwarIndian Journal of Critical Care Medicine 2018 22(2):116-118
Fondaparinux, a pentasaccharide administered for heparin-induced thrombocytopenia (HIT), can lead to the occurrence of thrombocytopenia. This patient underwent aortic stent graft placement for Salmonella paratyphi A-infected abdominal aortic aneurysm. Fondaparinux was administered for anticoagulation that led to a dramatic decline in his platelet counts. Investigations revealed HIT profile, PF4/heparin by particle gel immunoassay to be positive. Fondaparinux, a prescribed anticoagulant for HIT can paradoxically predispose to thrombocytopenia.

Source: Indian Journal of Critical Care Medicine - February 19, 2018 Category: Intensive Care Authors: Sonali Vadi Vishal Peshattiwar Source Type: research