Animal models of monoclonal immunoglobulin-related renal diseases

Animal models of monoclonal immunoglobulin-related renal diseasesAnimal models of monoclonal immunoglobulin-related renal diseases, Published online: 19 February 2018; doi:10.1038/nrneph.2018.8Monoclonal immunoglobulin deposition produces complex diseases with heterogeneous phenotypes, making it difficult to identify the underlying mechanisms of immunoglobulin aggregation and deposition. In this Review, the authors discuss animal models of various human immunoglobulin deposition diseases, and each model's drawbacks and contributions to our understanding of these diseases.

Source: Nature Reviews Nephrology - February 19, 2018 Category: Urology & Nephrology Authors: Christophe Sirac Guillermo A. Herrera Paul W. Sanders Vecihi Batuman Sebastien Bender Maria V. Ayala Vincent Javaugue Jiamin Teng Elba A. Turbat-Herrera Michel Cogn é Guy Touchard Nelson Leung Frank Bridoux Source Type: research