Hepcidin and proinflammatory markers in  children with chronic kidney disease: A case-control study
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CONCLUSION: A positive correlation between hepcidin and other inflammatory biomarkers in non-dialyzed, iron- and EPO-naïve pediatric CKD patients suggests a role of these markers in higher hepcidin production and its contribution to iron-restricted erythropoiesis across the spectrum of CKD. Median hepcidin levels were highest in those with impaired iron trafficking, followed by those with no iron deficiency, followed by those with absolute iron deficiency, suggesting that in an iron-replete state, high hepcidin levels inhibit iron absorption from the gut and release from iron storing cells, thus restricting erythropoiesis leading to anemia.
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PMID: 29451472 [PubMed - as supplied by publisher]

Source: Clinical Nephrology - February 16, 2018 Category: Urology & Nephrology Authors: Goyal KK, Saha A, Sahi PK, Kaur M, Dubey NK, Goyal P, Upadhayay AD Tags: Clin Nephrol Source Type: research