Negative Association Between Sclerostin and INSL3 in Isolated Human Osteocytes and in Klinefelter Syndrome: New Hints for Testis-Bone Crosstalk.

Conclusions: We report for the first time a negative association between the testicular hormone INSL3 and the osteocytic negative regulator of bone formation, sclerostin. We further explored this association in vitro, and showed that INSL3 was able to reduce sclerostin expression. These results add further knowledge on the emerging role of sclerostin as a therapeutic target for osteoporosis treatment.
PMID: 29452406 [PubMed - as supplied by publisher]

Source: The Journal of Clinical Endocrinology and Metabolism - February 14, 2018 Category: Endocrinology Authors: Di Nisio A, De Toni L, Rocca MS, Ghezzi M, Selice R, Taglialavoro G, Ferlin A, Foresta C Tags: J Clin Endocrinol Metab Source Type: research