Amelioration of renal structural changes in STZ-induced diabetic mice with ethanolic extract of Allium saralicum R.M. Fritsch

AbstractThe purpose of this study was to assess the hypoglycemic and protective activities of the ethanolic extract ofAllium saralicum (AS) in streptozotocin (STZ) induced diabetic mice. Diabetes was experimentally induced by intraperitoneal injection of STZ (60  mg/kg bw) in 35 mice. Fasting blood glucose (FBG) levels were measured everyday using glucometer strips. Mice with plasma glucose level> 250 mg/dL were considered diabetic. After 3 days, they were divided randomly into five groups. Groups 1 and 2 served as non-diabetic and untreated diabetic controls, respectively. Group 3 received 0.5 mg/kg glibenclamide orally. Groups 4 and 5 were given 200 and 400 μg/kg, respectively, of AS for 15 days orally. At 16th day, the animals were dissected and their kidney removed. The total volume of cortex, medulla, renal tubules, and glomeruli as well as the length of vessels and renal tubules was estimated using stereological method. Daily treatment of diabetic mice with high dose of AS significantly (p ≤ 0.05) declined FBG levels at days 10–13 of the experiment faster than glibenclamide. High dose of AS could significantly (p ≤ 0.05) improve the volume of cortex, glomeruli, proximal tubules, distal tubules, vessels, and total length of proximal tubules and vessels. Moreover, glomerular loss was significantly (p ≤ 0.05) inhibited with high dose of AS. It concluded thatAllium saralicum co...
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

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Date: Wednesday, 09 18, 2019; Speaker: Robert A. Star, MD, Director, Division of Kidney, Urologic, and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, NIH; Building: Building 10 (Clinical Center); Lipsett Amphitheater
Source: NIH Calendar of Events - Category: American Health Source Type: events
In conclusion, this multicenter study demonstrated an association between preoperative smoking and increased risk of infection following new DBS implantation surgery. Counseling about this risk should be considered in preoperative evaluation of patients who are considering undergoing a DBS procedure.
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
ConclusionsSerum hs-CRP level might be helpful as a predictor for the development of AKI in aSAH patients. Delayed cerebral ischemia occurrence rate and mortality of patients with AKI tend to be higher than those of patients without in this cohort; however, they were not significantly different.
Source: Acta Neurochirurgica - Category: Neurosurgery Source Type: research
Publication date: Available online 22 August 2019Source: Trends in Food Science &TechnologyAuthor(s): Ning Fang, Chunkai Wang, Xiaofeng Liu, Xue Zhao, Yanhua Liu, Xinmin Liu, Yongmei Du, Zhongfeng Zhang, Hongbo ZhangAbstractBackgroundAstaxanthin is a ketocarotenoid with stronger antioxidant activity than vitamin E and coenzyme Q10, and with pharmacological effects against cancer, cardiovascular disease, diabetes, inflammation, and others. Increased astaxanthin supplementation in food, nutraceuticals, and cosmetic products has resulted in tremendous growth in the demand for natural astaxanthin.Scope and approachAstaxant...
Source: Trends in Food Science and Technology - Category: Food Science Source Type: research
Publication date: Available online 21 August 2019Source: Artificial Intelligence in MedicineAuthor(s): Sebastian Spänig, Agnes Emberger-Klein, Jan-Peter Sowa, Ali Canbay, Klaus Menrad, Dominik HeiderAbstractArtificial intelligence (AI) will pave the way to a new era in medicine. However, currently available AI systems do not interact with a patient, e.g., for anamnesis, and thus are only used by the physicians for predictions in diagnosis or prognosis. However, these systems are widely used, e.g., in diabetes or cancer prediction.In the current study, we developed an AI that is able to interact with a patient (virtual...
Source: Artificial Intelligence in Medicine - Category: Bioinformatics Source Type: research
Conclusion: We describe the first case of fungal necrotising scleritis without intraocular inflammation following pars plana vitrectomy (PubMed Search). Infection should be kept in the differential diagnosis of post-operative necrotising scleritis even in the absence of risk factors like hypopyon or diabetes. Early recognition improves final outcome. Medical therapy should be continued even after presumed cure to take care of residual fungi and prevent recurrences. PMID: 31429609 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
Publication date: 1 November 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 183Author(s): Wen Yao Hu, Zhi Min Wu, Qian Qian Yang, Yue Jin Liu, Juan Li, Can Yang ZhangAbstractThe development of intelligent oral drug delivery carrier aiming at efficiently bring insulin to intestine is of great significance for diabetes mellitus therapy. In the present study, a series of amphiphilic pH-sensitive block copolymer poly(methyl methacrylate-co-methacrylicacid)-b-poly(2-amino ethyl methacrylate) [P(MMA-co-MAA)-b-PAEMA] was synthesized via activators regenerated by electron transfer atom transfer radical polymerization (...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
We present a comprehensive review and update of ACC inhibitors. We look at the current advance of ACC inhibitors in clinical studies and the implications in drug discovery. We searched ScienceDirect ( https://www.sciencedirect.com/ ), ACS ( https://pubs.acs.org/ ), Wiley ( https://onlinelibrary.wiley.com/ ), NCBI ( https://www.ncbi.nlm.nih.gov/ ) and World Health Organization ( https://www.who.int/ ). The keywords used were Acetyl-CoA Carboxylase, lipid, inhibitors and metabolic syndrome. All documents were published before June 2019. Expert opinion: The key regulatory role of ACC in fatty acid synthesis and oxidation path...
Source: Expert Opinion on Investigational Drugs - Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research
Over 2.6 million ED visits across the United States result in a primary diagnosis of urinary tract infection.1 While much attention has been paid to reducing blood culture contamination rates in the emergency department,2-9 a substantial gap remains in projects aimed at reducing contamination in clean-catch urine specimens obtained in the ED setting. Obtaining an adequate urine culture is clinically important to the care of several vulnerable patient groups, including patients with diabetes or compromised immune responses, those with high risk for subsequent urosepsis, previous antibiotic resistant infections, multiple ant...
Source: Journal of Emergency Nursing: JEN - Category: Nursing Authors: Tags: Editorial Source Type: research
Do children receiving growth hormone treatment realize improvements in health-related quality of life?Clinical Endocrinology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news
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