The paradox of marrow adipose tissue in anorexia nervosa
Anorexia nervosa (AN) is a psychiatric disorder characterized by inappropriate nutrient intake resulting in low body weight. Multiple hormonal adaptations facilitate decreased energy expenditure in this state of caloric deprivation including non-thyroidal illness syndrome, growth hormone resistance, and hypogonadotropic hypogonadism. Although these hormonal adaptations confer a survival advantage during periods of negative energy balance, they contribute to the long-term medical complications associated with AN, the most common of which is significant bone loss and an increased risk of fracture.
Source: Bone - Category: Orthopaedics Authors: Pouneh K. Fazeli, Anne Klibanski Tags: Full Length Article Source Type: research
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