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New treatment strategies for chronic kidney disease from the animal kingdom

(University of Veterinary Medicine -- Vienna) Biomimetics offers an innovative approach to solving human problems by imitating strategies found in nature. Medical research could also benefit from biomimetics, as a group of international experts from various fields, including a scientists from Vetmeduni Vienna, point out using the example of chronic kidney disease. In future research, they intend to study the mechanisms that protect the muscles, organs and bones of certain animals during extreme conditions such as hibernation. Nature Reviews.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Authors: Haroon S, Davenport A Abstract INTRODUCTION: Only a minority of patients with chronic kidney disease treated by hemodialysis are currently treated at home. Until relatively recently, the only type of hemodialysis machine available for these patients was a slightly smaller version of the standard machines used for in-center dialysis treatments. Areas covered: There are now an alternative generation of dialysis machines specifically designed for home hemodialysis. The home dialysis patient wants a smaller machine, which is intuitive to use, easy to trouble shoot, robust and reliable, quick to set-up and put ...
Source: Expert Review of Medical Devices - Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research
This really encouraging article appeared last week.EHR-Integrated Tools Help Improve Chronic Kidney Disease CareTreatment involving EHR-integrated tools and patient engagement strategies are effective in improving areas of chronic kidney disease care. By Kate MonicaApril 05, 2018 - A quality improvement program combining EHR-integrated tools and patient engagement strategies can significantly improve quality of care for patients with chronic kidney disease, according to new research published in the American Journal of Managed Care (AJMC).Over a one-year period, Sequist et al. observed 153 primary care physicians trea...
Source: Australian Health Information Technology - Category: Information Technology Authors: Source Type: blogs
American Journal of Transplantation, EarlyView.
Source: American Journal of Transplantation - Category: Transplant Surgery Authors: Source Type: research
AbstractObjectiveThe correlation of serum fibroblast growth factor 23 (FGF-23) and Klotho protein levels with bone mineral density (BMD) in maintenance hemodialysis (MHD) patients was analyzed.MethodsBetween January 2015 and November 2015, 125 MHD patients in our hospital were enrolled. Dual-energy X-ray absorptiometry was used to examine the BMD in the femoral neck and lumbar spine of MHD patients. The patients were divided into three groups: a normal bone mass group, an osteopenia group, and an osteoporosis group. An ELISA was performed to measure serum FGF-23, Klotho protein, and 1,25(OH)2VitD3 levels. Other parameters,...
Source: European Journal of Medical Research - Category: Research Source Type: research
Few studies have examined the relationship between non-immunological factors and glomerular filtration rate (GFR) decline in kidney transplant. Correction of these factors in native kidneys slows progression of chronic kidney disease. The aim of this study was to analyze the association between control of non-immunological factors and annual decline of GFR.
Source: Transplantation Proceedings - Category: Transplant Surgery Authors: Source Type: research
Few studies have examined the long-term risks of kidney removal to donors despite the increase of frequency in kidney transplantation. This is the 1st study to develop prediction models of chronic kidney disease (CKD) for the 1-year period after donor nephrectomy in living donors. A prospective cohort of patients who underwent donor nephrectomy from March 1, 2006, to December 31, 2016, at the Severance Hospital, Seoul, South Korea, was used. CKD was defined as a glomerular filtration rate (GFR)  
Source: Transplantation Proceedings - Category: Transplant Surgery Authors: Source Type: research
Long-term persistence of statin therapy provided an ongoing reduction in mortality among patients with and without a known history of CVD, and renoprotective effect on CKD patients. Until now, very few reports...
Source: Lipids in Health and Disease - Category: Lipidology Authors: Tags: Research Source Type: research
Conclusion: Renal parenchymal loss and duration of ischemia have impact on the follow-up renal function.
Source: Journal of Clinical Imaging Science - Category: Radiology Authors: Source Type: research
Boehringer Ingelheim and Eli Lilly and Company (NYSE:LLY) have announced an academic collaboration with the University of Oxford. EMPA-KIDNEY will investigate the effects of empagliflozin on the progression of kidney disease and the occurrence of cardiovascular death, in people with established chronic kidney disease with and without diabetes.
Source: World Pharma News - Category: Pharmaceuticals Tags: Featured Boehringer Ingelheim Business and Industry Source Type: news
by Joydeep Sarkar, Alka A. Potdar, Gerald M. Saidel Iron plays vital roles in the human body including enzymatic processes, oxygen-transport via hemoglobin and immune response. Iron metabolism is characterized by ~95% recycling and minor replenishment through diet. Anemia of chronic kidney disease (CKD) is characterized by a lack of synthesis of er ythropoietin leading to reduced red blood cell (RBC) formation and aberrant iron recycling. Treatment of CKD anemia aims to normalize RBC count and serum hemoglobin. Clinically, the various fluxes of iron transport and accumulation are not measured so that changes during diseas...
Source: PLoS Computational Biology - Category: Biology Authors: Source Type: research
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