Translational overview of cytokine inhibition in acute myocardial infarction and chronic heart failure

Many cytokines are currently under investigation as potential target to improve cardiac function and outcome in the setting of acute myocardial infarction (MI) or chronic heart failure (HF). Here we aim to provide a translational overview of cytokine inhibiting therapies tested in experimental models and clinical studies. In various experimental studies, inhibition of interleukin-1 (IL-1), -6 (IL-6), -8 (IL-8), monocyte chemoattractant protein-1 (MCP-1), CC- and CXC chemokines, and tumor necrosis factor- α (TNF-α) had beneficial effects on cardiac function and outcome.

Source: Trends in Cardiovascular Medicine - February 15, 2018 Category: Cardiology Authors: Minke H.T. Hartman, Hilde E. Groot, Irene Mateo Leach, Jacco C. Karper, Pim van der Harst Source Type: research