Cortactin recruits FMNL2 to promote actin polymerization and endosome motility in invadopodia formation

Recently, invadopodia have been increasingly recognized as important drivers of local invasion and metastasis. Cortactin, as an actin-binding protein, is closely associated with invadopodia through interacting with proteins. Formin-like 2 (FMNL2), a member of diaphanous-related formins which act as nucleation factors, plays an important role in tumor progression. But whether cortactin can interact with FMNL2 to promote invadopodia formation and the role of FMNL2 in invadopodia formation are still unknown.

Source: Cancer Letters - February 4, 2018 Category: Cancer & Oncology Authors: X.L. Ren, Y.D. Qiao, J.Y. Li, X.M. Li, D. Zhang, X.J. Zhang, X.H. Zhu, W.J. Zhou, J. Shi, W. Wang, W.T. Liao, Y.Q. Ding, L. Liang Tags: Original Articles Source Type: research